Results 1 to 10 of about 5,433,114 (412)

A multisociety Delphi consensus statement on new fatty liver disease nomenclature

open access: yesHepatology, 2023
The principal limitations of the terms NAFLD and NASH are the reliance on exclusionary confounder terms and the use of potentially stigmatising language.
M. Rinella   +52 more
semanticscholar   +1 more source

Characterization of Frequency-Dependent Material Properties of Human Liver and its Pathologies Using an Impact Hammer [PDF]

open access: yesMedical Image Analysis, 2011, Vol. 15, No.1, pp. 45-52, 2021
The current methods for characterization of frequency-dependent material properties of human liver are very limited. In fact, there is almost no data available in the literature showing the variation in dynamic elastic modulus of healthy or diseased human liver as a function of excitation frequency.
arxiv   +1 more source

Loss of 5-hydroxymethylcytosine induces chemotherapy resistance in hepatocellular carcinoma via the 5-hmC/PCAF/AKT axis

open access: yesCell Death and Disease, 2023
Multidrug resistance is a major challenge in treating advanced hepatocellular carcinoma (HCC). Although recent studies have reported that the multidrug resistance phenotype is associated with abnormal DNA methylation in cancer cells, the epigenetic ...
Xiao-Jun Guo   +17 more
doaj   +1 more source

NCSTN promotes hepatocellular carcinoma cell growth and metastasis via β-catenin activation in a Notch1/AKT dependent manner

open access: yesJournal of Experimental & Clinical Cancer Research, 2020
Background Hepatocellular carcinoma is the third top cause of cancer-related mortalities worldwide. The prognosis of HCC patients remains poor due to rapid progression and high incidence of tumor recurrence.
Hui Li   +11 more
doaj   +1 more source

Factors Prognostic of Survival in Liver Transplant Recipients with Hepatitis B Virus Related Acute-on-Chronic Liver Failure

open access: yesCanadian Journal of Gastroenterology and Hepatology, 2022
Objectives. Factors prognostic of survival in liver transplant (LT) recipients with hepatitis B virus related acute-on-chronic liver failure (HBV-ACLF) remain unclear.
Zhengjun Zhou   +6 more
doaj   +1 more source

MAFLD: A consensus-driven proposed nomenclature for metabolic associated fatty liver disease.

open access: yesGastroenterology, 2020
Fatty liver associated with metabolic dysfunction is common, affects a quarter of the population, and has no approved drug therapy. While pharmacotherapies are in development, response rates appear modest.
M. Eslam, A. Sanyal, J. George
semanticscholar   +1 more source

The role of RIPK1 mediated cell death in acute on chronic liver failure

open access: yesCell Death and Disease, 2021
Acute-on-chronic liver failure (ACLF) is characterized predominantly by non-apoptotic forms of hepatocyte cell death. Necroptosis is a form of programmed lytic cell death in which receptor interacting protein kinase (RIPK) 1, RIPK3 and phosphorylated ...
Takayuki Kondo   +13 more
doaj   +1 more source

Assessing Non-Invasive Liver Function in Patients With Intestinal Failure Receiving Total Parenteral Nutrition-Results From the Prospective PNLiver Trial [PDF]

open access: yes, 2020
Liver abnormalities in intestinal failure (IF) patients receiving parenteral nutrition (PN) can progress undetected by standard laboratory tests to intestinal failure associated liver disease (IFALD). The aim of this longitudinal study is to evaluate the
Bednarsch, Jan   +10 more
core   +1 more source

Integrative analyses identify CD73 as a prognostic biomarker and immunotherapeutic target in intrahepatic cholangiocarcinoma

open access: yesWorld Journal of Surgical Oncology, 2023
Background CD73 promotes progression in several malignancies and is considered as a novel immune checkpoint. However, the function of CD73 in intrahepatic cholangiocarcinoma (ICC) remains uncertain.
Bao-Ye Sun   +9 more
doaj   +1 more source

Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation. [PDF]

open access: yes, 2015
Reactive oxygen species (ROS) produced by nicotinamide adenine dinucleotide phosphate oxidase (NOX) play a key role in liver injury and fibrosis. Previous studies demonstrated that GKT137831, a dual NOX1/4 inhibitor, attenuated liver fibrosis in mice as ...
Brenner, David A   +2 more
core   +10 more sources

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