Results 121 to 130 of about 4,693,650 (362)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Adjuvant TACE Improves Prognosis After Resection in Dual-Phenotype Hepatocellular Carcinoma: A Propensity Score-Matched Study

Journal of Hepatocellular Carcinoma
Zijian Leng,1,* Taifeng Zhu,1,* Ziyue Huang,1,* Xiaokun Chen,1,* Yuce Lu,1 Yuehao Zhang,2 Xueshuai Wan,1 Xiaobo Yang,1 Lei Zhang,1 Haitao Zhao,1 Shunda Du,1 Zhonghai Zhao,3 Yongchang Zheng1 1Department of Liver Surgery ...
Leng Z, Zhu T, Huang Z, Chen X, Lu Y, Zhang Y, Wan X, Yang X, Zhang L, Zhao H, Du S, Zhao Z, Zheng Y   +12 more
doaj  

Liver transplantation in patients with situs inversus [PDF]

, 1990
Two patients with situs inversus and biliary atresia were treated with hepatic transplantation, one with an auxiliary liver and the other with an orthotopic graft which was placed using a piggy-back technique.
Hall, R, Starzl, TE, Todo, S, Tzakis, A
core  

Lysyl oxidase-like 3 restrains mitochondrial ferroptosis to promote liver cancer chemoresistance by stabilizing dihydroorotate dehydrogenase [PDF]

, 2023
Meixiao Zhan, Yufeng Ding, Shanzhou� Huang, Yuhang Liu, Jing Xiao, Hua Yu, Ligong Lu, Xiongjun Wang   +7 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Liver [PDF]

Laboratory Investigation, 2017
openaire   +5 more sources

A Multicenter Retrospective Study: Impact of First-Line Treatment Strategies on second-Line Efficacy and Safety of Regorafenib with or Without PD-1 Inhibitors in Unresectable Hepatocellular Carcinoma

Journal of Hepatocellular Carcinoma
Weihong Ma,1,2,* Yinyin Li,1,* Yinying Lu,1,2 Zhipeng Liang,3 Hongli Yu,1,2 Jie Han,1,2 Jiaqi Liu,1,2 Wenjing Wang,1,2 Caiyun Peng,1 Jiamin Cheng1 1Senior Department of Hepatology, The 5th Medical Center of the PLA General Hospital ...
Ma W, Li Y, Lu Y, Liang Z, Yu H, Han J, Liu J, Wang W, Peng C, Cheng J   +9 more
doaj  

Clinical value of liver ultrasound for the diagnosis of nonalcoholic fatty liver disease in overweight and obese patients [PDF]

, 2015
Fernando Bril, Carolina Ortiz‐Lopez, Romina Lomonaco, Beverly Orsak, Michael W. Freckleton, Kedar N. Chintapalli, Jean Hardies, Song Lai, Felipe Solano, Fermin O. Tio, Kenneth Cusi   +10 more
openalex   +1 more source

Hepatic Macrophages in Liver Injury [PDF]

, 2020
Zhao Shan, Cynthia Ju
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source