Results 121 to 130 of about 6,238,038 (408)

Hypoxia- and Anoikis-Related lncRNA Signature Defines Molecular Subtypes and Predicts Prognosis and Immunotherapy Response in Hepatocellular Carcinoma

Journal of Hepatocellular Carcinoma
Xiaohang Lu,1– 3,* Yunyong Wang,1,3,* Yuan Yu,4 Rongzhen Zhang,5 Fuli Long,5 Minpeng Li,4 Meng Pan,4 Kewei Du,6 Jinna Tan,1,3 Jiaqian He,1,3 Zongxian Li,7,8 Hongsheng Lin,1,6,* Mingfen Li1,6,* 1The First Affiliated ...
Lu X, Wang Y, Yu Y, Zhang R, Long F, Li M, Pan M, Du K, Tan J, He J, Li Z, Lin H, Li M   +12 more
doaj  

The prognostic value of microvascular invasion in early-intermediate stage hepatocelluar carcinoma: a propensity score matching analysis

BMC Cancer, 2018
Background Microvascular invasion (MVI) is well established as a negative prognostic factor for hepatocelluar carcinoma (HCC). However, its prognostic value in different subgroups of Barcelona Clinical Liver Cancer (BCLC) stages remains to be elucidated.
Junyi Shen, Jun Wen, Chuan Li, Tianfu Wen, Lvnan Yan, Bo Li, Jiayin Yang, Changli Lu   +7 more
doaj   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Open and / or laparoscopic surgical treatment of liver hydatic cysts [PDF]

, 2018
Hydatid disease is a severe parasitic disease with a widely ranging distribution. In the human being the liver is the most frequent organ affected. 1 The treatment should be individualized to the morphology, size, number and location of the cysts, that ...
Al Karowda‘a E. A., Codacci Pisanelli M., De Toma G., D’Andrea V., Izzo L., Izzo P., Izzo R., Izzo S., Messineo D., Pugliese F.   +9 more
core   +1 more source

Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations

Nature Communications, 2018
The liver is the largest solid organ in the body and is critical for metabolic and immune functions. However, little is known about the cells that make up the human liver and its immune microenvironment.
S. Macparland, Jeffrey C. Liu, Xuezhong Ma, Brendan T. Innes, A. Bartczak, B. K. Gage, J. Manuel, Nicholas Khuu, J. Echeverri, I. Linares, Rahul Gupta, Michael L Cheng, Lewis Y. Liu, Damra Camat, Sai W. Chung, Rebecca K Seliga, Zigong Shao, Elizabeth Lee, Shinichiro Ogawa, Mina Ogawa, M. Wilson, Jason E. Fish, M. Selzner, A. Ghanekar, D. Grant, P. Greig, G. Sapisochin, N. Selzner, N. Winegarden, O. Adeyi, G. Keller, Gary D Bader, I. McGilvray   +32 more
semanticscholar   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Evidence that host size determines liver size: Studies in dogs receiving orthotopic liver transplants [PDF]

, 1987
Orthotopic liver transplantation was performed in two groups of dogs; Group I animals consisted of large dogs that served as recipients of livers obtained from smaller dogs while Group II animals consisted of dogs that received liver from donor dogs of ...
Bucher, Bucher, Kahn, Koch, Leffert, Leffert, Leffert, McGowan, Morley, Putman, Richman, Rubin, Russell, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Strecker, Van Thiel, Van Thiel, Wagle   +28 more
core   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Liver cirrhosis-epidemiological and Clinical Aspects [PDF]

, 2008
Liver cirrhosis is the end-stage of many different chronic liver diseases. Limited data exists on the epidemiology, natural history and complications of liver cirrhosis such as esophageal varices and malignancies in the Nordic countries after the ...
Gunnarsdóttir, Steingerður Anna
core  

Fifteen years of clinical liver transplantation [PDF]

, 1979
Liver transplantation in humans was first attempted more than 15 yr ago. The 1-yr survival has slowly improved until it has now reached about 50%. In our experience, 46 patients have lived for at least 1 yr, with the longest survival being 9 yr. The high
Abouna, Absolon, Alper, Bechtelsheimer, Benichou, Birtch, Borel, Borel, Calne, Calne, Calne, Calne, Calne, Calne, Charles G. Halgrimson, Corman, Daloze, Demirleau, Fisch, Fonkalsrud, Fortner, Fortner, Garnier, Gerhard P.J. Schroter, Green, Groth, Groth, Hume, J. Hood, K.A. Porter, Koep, Lampe, Lawrence J. Koep, Lie, Machado, Marchioro, Martineau, McMaster, Moore, Moore, Moore, Peacock, Putnam, Richard Weil, Schroter, Schroter, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Thomas E. Starzl, Wall, Welch, Williams   +65 more
core   +1 more source