Results 161 to 170 of about 4,693,650 (362)

Alcoholic Liver Disease: Update on the Role of Dietary Fat [PDF]

, 2016
Irina Kirpich, Matthew Miller, Matthew C. Cave, Swati Joshi‐Barve, Craig J. McClain   +4 more
openalex   +1 more source

Alcohol-Associated Liver Disease Mortality Increased From 2017 to 2020 and Accelerated During the COVID-19 Pandemic

, 2022
Sasha Deutsch‐Link, Yue Jiang, Anne F. Peery, A. Sidney Barritt, Ramón Bataller, Andrew M. Moon   +5 more
openalex   +2 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

The greater impact of PNPLA3 polymorphism on liver‐related events in Japanese non‐alcoholic fatty liver disease patients: A multicentre cohort study [PDF]

, 2023
Yuya Seko, Kanji Yamaguchi, Toshihide Shima, Michihiro Iwaki, Hirokazu Takahashi, Miwa Kawanaka, Saiyu Tanaka, Yasuhide Mitsumoto, Masato Yoneda, Atsushi Nakajima, Ola Fjellström, Jenny E. Blau, Björn Carlsson, Takeshi Okanoue, Yoshito Itoh   +14 more
openalex   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Fully automated convolutional neural network-based affine algorithm improves liver registration and lesion co-localization on hepatobiliary phase T1-weighted MR images. [PDF]

, 2019
BackgroundLiver alignment between series/exams is challenged by dynamic morphology or variability in patient positioning or motion. Image registration can improve image interpretation and lesion co-localization.
Bittencourt, Leornado Kayat, Brunsing, Ryan L, Cunha, Guilherme Moura, Delgado, Timo, Fowler, Katie J, Hasenstab, Kyle A, Higaki, Atsushi, Hsiao, Albert, Ichikawa, Shintaro, Schlein, Alexandra, Schwartzman, Armin, Sirlin, Claude B, Wang, Kang   +12 more
core  

Arbutin alleviates fatty liver by inhibiting ferroptosis via FTO/SLC7A11 pathway

, 2023
Tianyu Jiang, Yao Xiao, Jinfeng Zhou, Zupeng Luo, Lin Yu, Qichao Liao, Siqi Liu, Xinyi Qi, Hao Zhang, Menglong Hou, Weiwei Miao, Batbold Batsaikhan, Turtushikh Damba, Yunxiao Liang, Yixing Li, Lei Zhou   +15 more
openalex   +1 more source

Suppression of FOXO1 attenuates inflamm‐aging and improves liver function during aging [PDF]

, 2023
Wanbao Yang, Da Mi Kim, Wen G. Jiang, Weiqi Ai, Quan Pan, Shahina Rahman, James J. Cai, Wesley Brashear, Yuxiang Sun, Shaodong Guo   +9 more
openalex   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Hepatoprotective Effect of Baicalein Against Acetaminophen-Induced Acute Liver Injury in Mice [PDF]

, 2018
Hongchao Zhou, Hui Wang, Kun Shi, Jianming Li, Ying Zong, Rui Du   +5 more
openalex   +1 more source