Results 171 to 180 of about 2,769,816 (316)

The Anatomy of the Liver

, 2010
This RLO outlines the anatomy of the ...
Vivian Rolfe
core  

Prometheus Revisited: From Liver to Heart. [PDF]

Liver Int
Riva MA.
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Socioeconomic Factors and Their Role in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Comprehensive Review. [PDF]

Liver Int
Wiering L, Demir M.
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Diagnostic performance of neck circumference for detecting steatotic liver disease in adults: a systematic review and meta-analysis protocol. [PDF]

BMJ Open
Abdurakhmanova E, Bolatbek A, Zholshybek N, Mustafa Z, Almazan J, Bolla SR.   +5 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Validating graft and standard liver size predictions in right liver living donor liver transplantation

, 2009
A formula was derived from 159 living liver donors to estimate the liver size of a normal subject in our previous study. Standard liver weight (g) = 218 + body weight (kg) x 12.3 + 51 (if male). The standard liver volume (SLV) is attained by a conversion
Lo, CM, Wong, Y, Ng, KKC, Chok, KSH, Fan, ST, Chan, SC   +5 more
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Steatotic Liver Disease at Primary Biliary Cholangitis Diagnosis: Association With Ursodeoxycholic Acid Response and Outcomes. [PDF]

Liver Int
Del Barrio M, Sala M, Gómez J, Horta D, Hernández-Guerra M, Salcedo M, Goñi S, Ríos-León R, Herreros ÁM, González-Santiago JM, Martínez J, Quintans NC, Ampuero J, Antón MD, Fernández-de la Varga M, Escudero D, El Hajra I, Cuenca Alarcón F, Lorente S, Andrade RJ, Riveiro-Barciela M, Castello I, Vergara M, Quiñones R, Arencibía Almeida A, Blanco Sampascual S, Leal C, García-Retortillo M, Pérez-Medrano I, Fernández-Bermejo M, Morillas RM, Gómez E, Tejedor-Tejada J, Roget M, Rodríguez-Tajes S, Alonso-Peña M, Álvarez-Cancelo A, Londoño MC, Díaz-González Á.   +38 more
europepmc   +1 more source