Results 21 to 30 of about 2,738,593 (315)

Adjuvant Transarterial chemoembolization does not influence recurrence-free or overall survival in patients with combined hepatocellular carcinoma and Cholangiocarcinoma after curative resection: a propensity score matching analysis

BMC Cancer, 2020
Background The prognosis of patients with combined hepatocellular carcinoma and intrahepatic cholangiocarcinoma (CHC) is usually poor, and effective adjuvant therapy is missing making it important to investigate whether these patients may benefit from ...
Wei-Ren Liu, Meng-Xin Tian, Chen-Yang Tao, Zheng Tang, Yu-Fu Zhou, Shu-Shu Song, Xi-Fei Jiang, Han Wang, Pei-Yun Zhou, Wei-Feng Qu, Yuan Fang, Zhen-Bin Ding, Jian Zhou, Jia Fan, Ying-Hong Shi   +14 more
doaj   +1 more source

KRAS acting through ERK signaling stabilizes PD-L1 via inhibiting autophagy pathway in intrahepatic cholangiocarcinoma

Cancer Cell International, 2022
Background While the correlation between PD-L1 expression and KRAS mutation has been previously reported in other solid tumors such as non-small cell lung cancer (NSCLC), whether PD-L1 can be modulated by ERK signaling downstream of KRAS in intrahepatic ...
Zheng Gao, Jia-Feng Chen, Xiao-Gang Li, Ying-Hong Shi, Zheng Tang, Wei-Ren Liu, Xin Zhang, Ao Huang, Xuan-Ming Luo, Qiang Gao, Guo-Ming Shi, Ai-Wu Ke, Jian Zhou, Jia Fan, Xiu-Tao Fu, Zhen-Bin Ding   +15 more
doaj   +1 more source

The impact of tumor burden at the initial hepatectomy on the recurrence-to-death survival after repeat surgical resection/radiofrequency ablation: a retrospective study

BMC Surgery, 2022
Background Previous studies have reported the surgical resection (SR) and radiofrequency ablation (RFA) could achieve comparable recurrence-to-death survival (RTDS).
Youwei Wu, Wei Peng, Junyi Shen, Xiaoyun Zhang, Chuan Li, Tianfu Wen   +5 more
doaj   +1 more source

ِAnalysis of donor motivations in living donor liver transplantation

Frontiers in Surgery, 2014
Objectives: The introduction of the living donor liver transplantation (LDLT) in Egypt as in elsewhere, has raised important psychological conflicts and ethical questions.
Hesham eAbdeldayem, Samy eKashkoush, Bassem Soliman Hegab, Amr eAziz, Hany eShoreem, Shereef eSaleh   +5 more
doaj   +1 more source

Integrative analyses identify CD73 as a prognostic biomarker and immunotherapeutic target in intrahepatic cholangiocarcinoma

World Journal of Surgical Oncology, 2023
Background CD73 promotes progression in several malignancies and is considered as a novel immune checkpoint. However, the function of CD73 in intrahepatic cholangiocarcinoma (ICC) remains uncertain.
Bao-Ye Sun, Zhang-Fu Yang, Zhu-Tao Wang, Gao Liu, Cheng Zhou, Jian Zhou, Jia Fan, Wei Gan, Yong Yi, Shuang-Jian Qiu   +9 more
doaj   +1 more source

Liver Regeneration after Liver Transplantation [PDF]

European Surgical Research, 2012
<b><i>Background/Purpose:</i></b> The liver has a remarkable capacity to regenerate after injury or resection. The aim of this review is to outline the mechanisms and factors affecting liver regeneration after liver transplantation.
A, Taki-Eldin, L, Zhou, H-Y, Xie, S-S, Zheng   +3 more
openaire   +2 more sources

Liver regeneration [PDF]

Journal of Cellular Physiology, 2007
AbstractLiver regeneration after partial hepatectomy is a very complex and well‐orchestrated phenomenon. It is carried out by the participation of all mature liver cell types. The process is associated with signaling cascades involving growth factors, cytokines, matrix remodeling, and several feedbacks of stimulation and inhibition of growth related ...
openaire   +2 more sources

The Efficacy and Safety of Hepatic Arterial Infusion Chemotherapy Based on FOLFIRI for Advanced Intrahepatic Cholangiocarcinoma as Second-Line and Successive Treatment: A Real-World Study

Canadian Journal of Gastroenterology and Hepatology, 2022
Objective. Intrahepatic cholangiocarcinoma (iCCA) is a primary liver malignancy with a poor prognosis and limited treatment. Cisplatin with gemcitabine is used as the standard first-line chemotherapy regimen; however, there is still no robust evidence ...
Peixin Huang, Xiaoyong Huang, Yingting Zhou, Guohuan Yang, Qiman Sun, Guoming Shi, Yi Chen   +6 more
doaj   +1 more source

SQSTM1/p62 in intrahepatic cholangiocarcinoma promotes tumor progression via epithelial–mesenchymal transition and mitochondrial function maintenance

Cancer Medicine, 2023
Background SQSTM1/p62 is a selective autophagy receptor that regulates multiple signaling pathways participating in the initiation and progression of tumors.
Jiafeng Chen, Zheng Gao, Xiaogang Li, Yinghong Shi, Zheng Tang, Weiren Liu, Xin Zhang, Ao Huang, Xuanming Luo, Qiang Gao, Guangyu Ding, Kang Song, Jian Zhou, Jia Fan, Xiutao Fu, Zhenbin Ding   +15 more
doaj   +1 more source

Liver Transplantation [PDF]

Seminars in Liver Disease, 1999
Since the first human liver transplant done in 1963, the procedure has become a routine procedure with an excellent outcome in terms both of quality and of length of survival. The development and introduction into clinical practice of a variety of immunosuppressive agents has given the clinician a bewildering array of therapeutic options but with a ...
openaire   +4 more sources