Results 41 to 50 of about 4,693,650 (362)

Serial circulating tumor DNA to predict early recurrence in patients with hepatocellular carcinoma: a prospective study

Molecular Oncology, 2022
We studied the value of circulating tumor DNA (ctDNA) in predicting early postoperative tumor recurrence and monitoring tumor burden in patients with hepatocellular carcinoma (HCC).
Gui‐Qi Zhu, Wei‐Ren Liu, Zheng Tang, Wei‐Feng Qu, Yuan Fang, Xi‐Fei Jiang, Shu‐Shu Song, Han Wang, Chen‐Yang Tao, Pei‐Yun Zhou, Run Huang, Jun Gao, Hai‐Xiang Sun, Zhen‐Bin Ding, Yuan‐Fei Peng, Zhi Dai, Jian Zhou, Jia Fan, Ying‐Hong Shi   +18 more
doaj   +1 more source

A new liver perfusion and preservation system for transplantation Research in large animals [PDF]

, 1990
A kidney perfusion machine, model MOX-100 (Waters Instruments, Ltd, Rochester, MN) was modified to allow continuous perfusion of the portal vein and pulsatile perfusion of the hepatic artery of the liver. Additional apparatus consists of a cooling system,
A. Jake Demetris, Belzer F O, Denmark S W, Greenway C V, Guy Lebeau, Hoffmann R M, Jamieson N V, Katsuhiko Yanaga, Leonard Makowka, Mitsuo Shimada, Moore F D, Ruey Rong Hwang, Saburo Kakizoe, Starzl T E, Starzl T E, Starzl T E, Thomas E. Starzl, Williams J W   +17 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Management of Wilson disease across Europe: an international physician-oriented survey by the ERN-RARE Liver group

Orphanet Journal of Rare Diseases
Background Wilson disease (WD) is a rare disorder resulting in copper overload. Diagnosis and treatment are complex and highly specialized. We aimed to investigate the management of WD across Europe in line with the mission and framework of the European ...
Frederik Teicher Kirk, Karina Stubkjær Rewitz, Zoe Mariño, Eduardo Couchonnal, Nicolas Lanthier, Wiebke Papenthin, Marina Berenguer, Aurelia Poujois, Dominique Debray, Aftab Ala, Luis García-Villarreal, Tudor Lucian Pop, Gerald Denk, Piotr Socha, Thomas Damgaard Sandahl   +14 more
doaj   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Post-Transcriptional Regulation of Hepatic DDAH1 with TNF Blockade Leads to Improved eNOS Function and Reduced Portal Pressure In Cirrhotic Rats

Scientific Reports, 2017
Portal hypertension (PH) is a major cause of morbidity and mortality in chronic liver disease. Infection and inflammation play a role in potentiating PH and pro-inflammatory cytokines, including TNF, are associated with severity of PH.
V. Balasubramanian, G. Mehta, H. Jones, V. Sharma, N. A. Davies, R. Jalan, R. P. Mookerjee   +6 more
doaj   +1 more source

Successful use of the left portal vein as graft for middle hepatic vein reconstruction in left hemihepatectomy: preliminary experience on six cases

World Journal of Surgical Oncology, 2019
Background The purpose of this research was to assess the feasibility of reconstructing the middle hepatic vein (MHV) with resected left portal vein during left hemihepatectomy.
Tao Lv, Ling Xiang Kong, Jiayin Yang, Hong Wu, Tianfu Wen, Li Jiang, Jian Yang   +6 more
doaj   +1 more source

Mutual Zonated Interactions of Wnt and Hh Signaling Are Orchestrating the Metabolism of the Adult Liver in Mice and Human

, 2019
The Hedgehog (Hh) and Wnt/β-Catenin (Wnt) cascades are morphogen pathways whose pronounced influence on adult liver metabolism has been identified in recent years.
Aleithe, S., Brosch, M., Brusch, L., Damm, G., Gajowski, R., Gebhardt, R., Hampe, J., Hoehme, S., Hoffmann, U., Kolbe, E., Kücken, M., Matz-Soja, M., Meierhofer, D., Ott, F., Rennert, C., Schafmayer, C., Seehofer, D., Seifert, M., Spormann, L., Stöpel, C., von Schoenfels, W.   +20 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

CD4+CD25+CD127low regulatory T cells play predominant anti-tumor suppressive role in hepatitis B virus associated hepatocellular carcinoma

Frontiers in Immunology, 2015
Background:Hepatocellular carcinoma (HCC) is the second leading cause of cancer death worldwide and hepatitis B is one of the commonest causes. T regulatory cells (Tregs) are strong immunomodulators and are likely to play a major role in HCC development.
Shreya eSharma, Ritu eKhosla, Paul eDavid, Archana eRastogi, Ashish eVyas, Dileep eSingh, Ankit eBhardwaj, Amrish eSahney, Rakhi eMaiwall, Shiv Kumar Sarin, Nirupma eTrehanpati   +10 more
doaj   +1 more source