Results 251 to 260 of about 1,087,915 (317)

Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy

Advanced Healthcare Materials, EarlyView.
Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima, Sarmila Majumder, Divya S. Patel, Chunyu Hu, Hong Li, Xin Huang, Kim Truc Nguyen, Jacob Doon‐Ralls, Chiranth K. Nagaraj, Mangesh D. Hade, Setty M. Magaña, Eswar Shankar, Xiaoli Zhang, Daniel G. Stover, Bhuvaneswari Ramaswamy, Eduardo Reátegui   +15 more
wiley   +1 more source

Association of second-hand tobacco smoking with liver cancer, and interaction with HBV infection in a Chinese population-based case-control study. [PDF]

Environ Epidemiol
Liu X, Baecker A, Wu M, Zhou JY, Jin ZY, Fang F, Jung SY, Mu L, He N, Qu W, Zhang X, Li L, Zhao JK, Zhang ZF.   +13 more
europepmc   +1 more source

A Fully Human Engineered Bone Niche With Endogenous Osteoclastogenesis Reveals Osteoclast‐Dependent Osteomimicry in Prostate Cancer Cells

Advanced Healthcare Materials, EarlyView.
A human 3D bone niche integrating osteoblasts and osteoclasts enables co‐culture with prostate cancer cell lines and patient‐derived organoids. The engineered niche (i) models aspects of reciprocal phenotypic regulation between osteoblasts and cancer cells, (ii) captures osteoclast‐enhanced osteomimicry in tumor cells, and (iii) establishes a ...
Andrea Mazzoleni, Robin Dolgos, Thomas Menter, Boris Dasen, Arnaud Scherberich, Clémentine Le Magnen, Manuele G. Muraro, Ivan Martin   +7 more
wiley   +1 more source

Persistent interferon signaling and clonal expansion mark early events in DNA methylation damage-induced liver cancer. [PDF]

NAR Cancer
Pribyl LJ, Kay JE, Corrigan JJ, Volk LB, Norales M, Owiti NA, Kowal EA, Kohale IN, Nazari IS, Swanson MR, Moise AC, Ma D, Levine SS, Michelsen EM, Croy RG, Ragan T, Torous DK, Avlasevich SL, Dertinger SD, Carrasco SE, Samson LD, Essigmann JM, White FM, Engelward BP.   +23 more
europepmc   +1 more source

Functional Blood‐Brain Barrier Crossing by Biomimetic M13 Phage Vectors for Targeted Neuronal Delivery

Advanced Healthcare Materials, EarlyView.
This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino, Lucia Pappagallo, Francesca De Chirico, Luca Boselli, Hazem Ahmed, Luca Spagnoletti, Giovanni Pittaluga, Paolo Emidio Costantini, Matteo Calvaresi, Pier Paolo Pompa, Alberto Danielli, Fabio Benfenati, Valentina Castagnola   +12 more
wiley   +1 more source

A Systematic Study of GelMA‐Carbopol Bioinks for High‐Fidelity Extrusion 3D Bioprinting at Physiological Temperatures

Advanced Healthcare Materials, EarlyView.
Gonzalez Martinez and collaborators develop a strategy to formulate high performance GelMA‐based bioinks with low solids contents. The resulting bioinks enable 3D bioprinting at 37 °C of high‐fidelity structures with tunable mechanical properties that support high cell viability and function.
David A. González‐Martínez, Aidee V. Arizpe Tafoya, Eduardo González‐Martínez, Mabel Barreiro Carpio, Laura Daniela Serrano Andrade, Christopher T. N. Chow, Mohammadhossein Dabaghi, Jeremy A. Hirota, Jose M. Moran‐Mirabal   +8 more
wiley   +1 more source

Editorial: Liver cancer awareness month 2024: current progress and future prospects on advances in primary liver cancer investigation and treatment. [PDF]

Front Oncol
Tustumi F, das Neves RX, Pereira MA, Andraus W, Coelho FF.   +4 more
europepmc   +1 more source

A Versatile Microfluidic Extrusion‐Based Hydrogel Platform for Self‐Organization and Long‐Term Maintenance of Engineered 3D Lymphatic Endothelium

Advanced Healthcare Materials, EarlyView.
Microfluidic coaxial extrusion generates size‐controlled 3D lymphatic tubes from primary human dermal lymphatic endothelial cells in a defined four‐component matrix. These engineered vessels self‐organize into stable lymphatic endothelium, maintain selective macromolecular permeability for 30 days, and enable direct comparison with blood endothelial ...
Elsa Mazari‐Arrighi, Adeline Boyreau, Laura Chaillot, Wilfried Souleyreau, Laetitia Andrique, Pierre‐Olivier Guichet, Thomas Mathivet, Andreas Bikfalvi, Pierre Nassoy   +8 more
wiley   +1 more source

Metabolites involvement in the growth and spread of liver cancer. [PDF]

Liver Res
Gautam AK, Kumar V, Sonkar AB, Singh A, Yadav D, Rajan N, Kumar P, Singh S, Saha S, Mahalingam Rajamanickam V.   +9 more
europepmc   +1 more source

USP25 aggravates liver cancer development and impairs chemosensitivity by limiting LATS1 activation. [PDF]

EMBO Rep
Li L, Wang X, Yang Y, Zhou Y, Jiang Z, Zhai L, Zhao X, Qiang H, Luo J, Ji Y, Yao J, Zhang T, Wang Y, Li K, Chen L, Chen Y, Yuan J, Li Y.   +17 more
europepmc   +1 more source