Results 51 to 60 of about 59,179 (315)

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source

Analysis of IL2/IL21 Gene Variants in Cholestatic Liver Diseases Reveals an Association with Primary Sclerosing Cholangitis [PDF]

, 2011
Background/Aims: The chromosome 4q27 region harboring IL2 and IL21 is an established risk locus for ulcerative colitis (UC) and various other autoimmune diseases.
Denk, Gerald Ulrich, Brand, Stephan, Burkhard Göke, Göke, Burkhard, Stephan Brand, Rüdiger Paul Laubender, Christian Rust, Johannes Stallhofer, Jürgen Glas, Laubender, Rüdiger Paul, Glas, Jürgen, Pusl, Thomas, Thomas Pusl, Gerald Ulrich Denk, Stallhofer, Johannes, Rust, Christian   +15 more
core   +1 more source

Overview of Biliary Atresia

대한영상의학회지, 2022
Biliary atresia is a progressive, idiopathic, obliterative disease of the extrahepatic biliary tree that presents with biliary obstruction in the neonatal period. It is the most common indication for liver transplantation in children.
Tae Yeon Jeon
doaj   +1 more source

Primary bilial cholangitis: a new definition of the disease, current aspects of diagnosis and treatment. Literature review

Клинический разбор в общей медицине, 2023
Primary biliary cholangitis (PBC) is a chronic autoimmune cholestatic liver disease characterized by T-lymphocyte-mediated damage to intrahepatic biliary epithelial cells and the presence of a specific serological marker, antimitochondrial antibodies ...
Dmitry I. Trukhan
doaj   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

Thirteen-Year Follow-Up of a Patient with Liver Cirrhosis Resulting from the Overlap Syndrome of Autoimmune Hepatitis and Primary Biliary Cholangitis: Severe COVID-19 and Liver Transplantation

Российский журнал гастроэнтерологии, гепатологии, колопроктологии
Aim: to present the difficulties of long-term management of a patient with liver cirrhosis in the outcome of overlap syndrome (autoimmune hepatitis and primary biliary cholangitis) who suffered from severe COVID-19 infection.Key points.
A. Kh. Odintsova, D. R. Akberova, L. R. Sadykova, N. A. Cheremina, M. M. Minnullin, A. A. Kirshin, E. N. Gabitova, A. Yu. Khasanshina, D. I. Abdulganieva   +8 more
doaj   +1 more source

Dose adaptation of drugs in patients with liver disease [PDF]

, 2009
A detailed introduction into the topic was obtained by developing a German-language online course named “Dose adjustment in Patients with Liver Disease” for the “Swiss Virtual Campus” in collaboration with PNN AG, a spin-off company of the ETH Zurich.
Schlatter-Häner, Chantal
core   +1 more source

Amiloride reduces portal hypertension in rat liver cirrhosis [PDF]

, 2010
Objective This study aimed to investigate the effect of amiloride on portal hypertension. Amiloride is known to inhibit Na(+)/H(+) exchangers on activated hepatic stellate cells.
C. J. Steib, M. Hennenberg, A. C. Hartmann, Gerbes, Alexander L., Hartmann, Anna C., M. Bystron, Steib, Christian J., De Toni, Enrico N., Hennenberg, Martin, F. Beitinger, A. L. Gerbes, Beitinger, Frigga, Bystron, Markus, E. N. De Toni   +13 more
core   +1 more source

Colangiopatia auto-imune.

Acta Médica Portuguesa, 2001
We report two patients with mixed characteristics of primary biliary cirrhosis and autoimmune hepatitis. They are two female patients in their fifties (54 and 58 years-old) one of them with autoimmune phenomenon, rheumatoid arthritis and Sjögren syndrome.
R Marinho, H Graça, F Ramalho, A Costa, A Batista, M C De Moura   +5 more
doaj   +1 more source