Results 71 to 80 of about 59,179 (315)

Optimized Ex Vivo Human Liver Slice Culture Maintains Extended Viability and Function for Hepatotoxicity Testing

Advanced Science, EarlyView.
An optimized ex vivo human liver slice culture system preserves tissue architecture, hepatocyte function, and immune‐stromal complexity for at least five days. By refining slice thickness, oxygenation, air‐liquid interface, and extracellular matrix support, the platform enables human‐relevant hepatotoxicity testing and mechanistic studies, offering a ...
Huiche Feng, Cinzia Esposito, Andrej Benjak, Matthias S. Matter, Miriam Cieri, Camilla De Carlo, Philipp Sedlaczek, Fabian Haak, Mattia Marinucci, Gabriel Fridolin Hess, Otto Kollmar, Mairene Coto‐Llerena, Luca Di Tommaso, Visar Vela, Lukas Bubendorf, Luigi M. Terracciano, Charlotte K. Y. Ng, Salvatore Piscuoglio   +17 more
wiley   +1 more source

Serum hyaluronate as a non-invasive marker of hepatic fibrosis and inflammation in HBeAg-negative chronic hepatitis B [PDF]

, 2005
Background: HBV infection is a serious global heath problem. It is crucial to monitor this disease more closely with a non-invasive marker in clinical trials.
Montazeri, G., Estakhri Arezoo, Estakhri, A., Malekzadeh, R., Samiee Shahram, Mohammadkani, A., Samiee, S., Mohamadkhani, A., Farhad Zamani, Shahram Samiee, Montazeri Ghodrat, Zamani, F., Mohammadkani Ashraf, Derakhshan, M.H., Zamani Farhad, Montazeri, F., Nouri, N., Montazeri Farhad, Ghodrat Montazeri, Derakhshan Mohammad, Mohammad Hossain Derakhshan, Malekzadeh Reza, Ashraf Mohammadkani, Farhad Montazeri, Negin Nouri, Mohamadnejad Mehdi, Arezoo Estakhri, Nouri Negin, Mohamadnejad, M., Mehdi Mohamadnejad, Reza Malekzadeh   +30 more
core   +1 more source

Melatonin Alleviates Graft Biliary Fibrosis by Inhibiting VIM+ Cholangiocyte Subcluster via Hypoxia/TGF‐β‐CREM‐VIM Axis

Advanced Science, EarlyView.
Single‐cell RNA sequencing verified the presence of the VIM+ biliary epithelial cell (BEC) in the bile ducts of NAS patients. The hypoxia/TGF‐β‐CREM‐VIM axis mediated phenotypic switch toward VIM+ BEC is validated using a hypoxia/TGF‐β‐stimulated cellular model, a rat liver transplantation model, BEC‐specific Crem conditional knockout rats, and BEC ...
Zhaoyi Wu, Nengsheng Fu, Zhongxin Huang, Yu Mou, Ensi Ma, Xiaoshi Wang, Tian Dong, Yujun Zhang, Danqing Liu, Di Jiang, Jingya Kuang, Rui Liao, Yifeng Tao, Leida Zhang, Chengcheng Zhang   +14 more
wiley   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

Autonomic and sensory nerve dysfunction in primary biliary cirrhosis [PDF]

, 2004
AIM: Cardiovascular autonomic and peripheral sensory neuropathy is a known complication of chronic alcoholic and non-alcoholic liver diseases. We aimed to assess the prevalence and risk factors for peripheral sensory nerve and autonomic dysfunction using
Horváth, Andrea, Lakatos, Péter László, Csák, Tímea, Szalay, Ferenc, Istenes, Ildikó, Varga, Péter, Kempler, Péter, Keresztes, Katalin, Folhoffer, Anikó   +8 more
core  

Pathologic analysis of liver transplantation for primary biliary cirrhosis [PDF]

, 1988
A retrospective histopathologic review of all pathologic specimens from 394 adult liver transplant patients was undertaken with clinical correlation to determine if primary biliary cirrhosis has affected the posttrans‐plant course compared to all other ...
Markus, BH, Sysyu, GD, Esquivel, C, Gordon, R, Van Thiel, DH, Makowka, L, Sysyn, GD, Starzl, TE, Demetris, AJ, Saidman, S   +9 more
core   +1 more source

Microalgae Hybrid Biosystem for Enhanced Oral Delivery of Rifaximin in Hepatic Encephalopathy Treatment

Advanced Science, EarlyView.
The microalgae‐nanoparticle hybrid system with antibacterial activity can improve the oral delivery and therapeutic efficiency for hepatic encephalopathy treatment. Oral administration of the system can reduced systemic ammonia levels, enhanced intestinal barrier function, attenuated systemic and neuroinflammation, ameliorated cognitive impairments ...
Kaiyue Wang, Xueting Huang, Lingxiao Yang, Jin Liu, Lei Lei, Shaomin Zou, Kai Wang, Min Zhou, Zhe Tang   +8 more
wiley   +1 more source

Hepatic Copper Accumulation in Patients with Primary Biliary Cirrhosis [PDF]

, 1993
1993-03Liver biopsy specimens from 18 patients with primary biliary cirrhosis were examined histochemically and by energy-dispersive x-ray microanalysis. Using two indices, we classified hepatic copper accumulation into three stages based on the Cu x-ray
KATO, SHOSHI, ARAO, MOTOHIRO, SAKAMOTO, NOBUO, YAGI, AKIRA, KURIKI, JUNSUKE, HAYASHI, HISAO, YANO, MOTOYOSHI, TAKIKAWA, TOSHIKUNI, TAKESHIMA, HIROTOMO   +8 more
core   +1 more source

Autoimmune liver diseases: internist’s guide from bench to bedside

Italian Journal of Medicine, 2015
Autoimmune liver diseases are disorders of unknown etiology and immune pathogenesis, characterized by liver parenchyma inflammation (autoimmune hepatitis) or by lesions of the intralobular biliary ducts (primary biliary cirrhosis) or of the entire ...
Mario Visconti
doaj   +1 more source

Atypical primary biliary cholangitis results in vanishing bile duct syndrome with cutaneous xanthomas: a case report

Diagnostic Pathology, 2022
Background Vanishing bile duct syndrome (VBDS) is a rare but potentially severe acquired chronic cholestatic liver disease. Bile duct deficiency is a reduction of bile ducts in the liver, which can eventually lead to cholestatic liver disease and ...
Yuebo Jia, Lin Liu, Baocheng Deng, Yu Huang, Jiaqi Zhao, Guang Bai   +5 more
doaj   +1 more source