Results 1 to 10 of about 4,431,933 (293)

Primary Biliary Cholangitis and Primary Sclerosing Cholangitis: Current Knowledge of Pathogenesis and Therapeutics

Biomedicines, 2022
Cholangiopathies encompass various biliary diseases affecting the biliary epithelium, resulting in cholestasis, inflammation, fibrosis, and ultimately liver cirrhosis.
Ji-Won Park, Jung-Hee Kim, Sung-Eun Kim, Jang Han Jung, Myoung-Kuk Jang, Sang-Hoon Park, Myung-Seok Lee, Hyoung-Su Kim, Ki Tae Suk, Dong Joon Kim   +9 more
doaj   +5 more sources

Primary Biliary Cholangitis

Clinics in Liver Disease
Primary biliary cholangitis is a chronic, autoimmune, cholestatic disease that mainly affects women aged 40-70 years. Recent epidemiological studies have shown an increasing incidence worldwide despite geographical heterogeneity and a decrease in the ...
Stuart Gordon, Muhammad Salman Faisal, Humberto C Gonzalez   +2 more
exaly   +6 more sources

A phase II, randomized, open-label, 52-week study of seladelpar in patients with primary biliary cholangitis

Journal of Hepatology, 2022
BACKGROUND & AIMS We examined the efficacy and safety of seladelpar, a selective peroxisome proliferator-activated receptor-delta agonist, in adults with primary biliary cholangitis (PBC) at risk for disease progression (alkaline phosphatase [ALP] ≥1.67 ...
David Sheridan, Cynthia Levy
exaly   +2 more sources

Current Treatment of Primary Biliary Cholangitis and Primary Sclerosing Cholangitis: A Comprehensive Review [PDF]

The Turkish Journal of Gastroenterology
Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are chronic cholestatic liver diseases characterized by bile duct injury that may progress to fibrosis, cirrhosis, liver failure, and malignancy and ultimately require liver ...
Victoria E. Abadi-Ron, Ana Marenco-Flores, Natalia Rojas-Amaris, Fernando Munguía, Javier olo-Ibarra, Behnam Saberi, Vilas R. Patwardhan, Alan Bonder   +7 more
doaj   +2 more sources

Lipidome remodeling in primary biliary cholangitis [PDF]

Lipids in Health and Disease
Primary biliary cholangitis (PBC) is a chronic, cholestatic liver disease characterized by progressive destruction of intrahepatic bile ducts, impaired bile flow, and complex disturbances in bile acid and lipid metabolism.
Magdalena Rogalska, Paweł Rogalski, Aleksandra Andrzejuk, Agnieszka Błachnio-Zabielska, Piotr Zabielski, Robert Flisiak   +5 more
doaj   +2 more sources

Risks of colorectal cancer and biliary cancer according to accompanied primary sclerosing cholangitis in Korean patients with ulcerative colitis: a nationwide population-based study [PDF]

Intestinal Research, 2023
Background/Aims We conducted a nationwide population-based study to investigate incidence rates of colorectal and biliary cancers according to accompanying primary sclerosing cholangitis in Korean ulcerative colitis patients.
Eun Hye Oh, Ye-Jee Kim, Minju Kim, Seung Ha Park, Tae Oh Kim, Sang Hyoung Park   +5 more
doaj   +1 more source

Peroxisome Proliferator-Activated Receptors Regulate Hepatic Immunity and Assist in the Treatment of Primary Biliary Cholangitis

Frontiers in Immunology, 2022
Fibrates, which are agonists of peroxisome proliferator-activated receptor alpha, have received increasing attention in the treatment of primary biliary cholangitis.
Chang Wang, Chang Wang, Ying Shi, Ying Shi, Xiaomei Wang, Xiaomei Wang, Heming Ma, Heming Ma, Quan Liu, Yanhang Gao, Yanhang Gao, Junqi Niu, Junqi Niu   +12 more
doaj   +1 more source

Overlap syndrome of primary biliary cholangitis and primary sclerosing cholangitis: two case reports

Journal of Medical Case Reports, 2023
Background Overlap syndrome between primary biliary cholangitis and primary sclerosing cholangitis is an extremely rare condition that has been reported in only few published cases so far in the literature.
Haythem Yacoub, Sarra Ben Azouz, Hajer Hassine, Habiba Debbabi, Dhouha Cherif, Feriel Ghayeb, Seif Boukriba, Héla Kchir, Nadia Maamouri   +8 more
doaj   +1 more source

Primary biliary cholangitis

Вестник трансплантологии и искусственных органов, 2021
Primary biliary cholangitis (PBC), formerly known as primary biliary cirrhosis, is an organ-specific autoimmune disease predominantly affecting middle-aged women. It does not occur in children.
I. M. Iljinsky, O. M. Tsirulnikova
doaj   +1 more source

Mast Cells in Immune-Mediated Cholangitis and Cholangiocarcinoma

Cells, 2022
Cholestasis, which is impaired bile flow from the liver into the intestine, can be caused by cholangitis and/or bile duct obstruction. Cholangitis can arise from bacterial infections and cholelithiasis, however, immune-mediated cholangitis in primary ...
Marisol I. González, Danielle T. Vannan, Bertus Eksteen, Irán Flores-Sotelo, José Luis Reyes   +4 more
doaj   +1 more source