Results 31 to 40 of about 4,431,933 (293)

PPAR agonists for the treatment of primary biliary cholangitis: Old and new tales

Journal of Translational Autoimmunity, 2023
Introduction Primary biliary cholangitis (PBC) is an autoimmune liver disease involving the small intrahepatic bile ducts; when untreated or undertreated, it may evolve to liver fibrosis and cirrhosis.
F. Colapietro, M. Gershwin, A. Lleo
semanticscholar   +1 more source

Drug therapy of primary biliary diseases: classical and modern strategies [PDF]

, 2013
Definition: Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are both cholestatic liver diseases. A common feature of these disorders is the accumulation of bile acids in the liver and blood, presumably because of decreased ...
Leuschner, Ulrich, Schlichting, Julia
core   +1 more source

Setanaxib, a first‐in‐class selective NADPH oxidase 1/4 inhibitor for primary biliary cholangitis: A randomized, placebo‐controlled, phase 2 trial

Liver international (Print), 2023
Primary biliary cholangitis (PBC) is a rare liver disease with significant unmet need for second‐line/add‐on treatments. Setanaxib, a NOX1/4 inhibitor, has shown anti‐fibrotic effects in in vitro and animal studies.
P. Invernizzi, M. Carbone, David C. Jones, C. Levy, Nicola Little, P. Wiesel, F. Nevens   +6 more
semanticscholar   +1 more source

Analysis of IL2/IL21 Gene Variants in Cholestatic Liver Diseases Reveals an Association with Primary Sclerosing Cholangitis [PDF]

, 2011
Background/Aims: The chromosome 4q27 region harboring IL2 and IL21 is an established risk locus for ulcerative colitis (UC) and various other autoimmune diseases.
Denk, Gerald Ulrich, Brand, Stephan, Burkhard Göke, Göke, Burkhard, Stephan Brand, Rüdiger Paul Laubender, Christian Rust, Johannes Stallhofer, Jürgen Glas, Laubender, Rüdiger Paul, Glas, Jürgen, Pusl, Thomas, Thomas Pusl, Gerald Ulrich Denk, Stallhofer, Johannes, Rust, Christian   +15 more
core   +1 more source

Liver stiffness measurement by vibration-controlled transient elastography improves outcome prediction in primary biliary cholangitis.

Journal of Hepatology, 2022
BACKGROUND & AIMS Liver stiffness measurement (LSM) by vibration-controlled transient elastography (VCTE) was shown to predict outcomes of primary biliary cholangitis (PBC) in small-size studies.
C. Corpechot, F. Carrat, F. Gaouar, F. Chau, G. Hirschfield, A. Gulamhusein, A. Montano-Loza, E. Lytvyak, C. Schramm, A. Parés, Ignasi Olivas, John E. Eaton, Karim T. Osman, G. Dalekos, N. Gatselis, F. Nevens, N. Cazzagon, Alessandra Zago, F. Russo, Nadir Abbas, P. Trivedi, D. Thorburn, F. Saffioti, L. Barkai, D. Roccarina, V. Calvaruso, A. Fichera, Adèle Delamarre, Esli Medina-Morales, A. Bonder, V. Patwardhan, C. Rigamonti, M. Carbone, P. Invernizzi, L. Cristoferi, A. V. D. van der Meer, R. D. de Veer, E. Zigmond, Eyal Yehezkel, A. Kremer, A. Deibel, J. Dumortier, Tony Bruns, K. Große, G. Pageaux, A. Wetten, J. Dyson, David Jones, O. Chazouilleres, B. Hansen, V. de Lédinghen   +50 more
semanticscholar   +1 more source

P-105 PREVALENCE OF ANTIMITOCHONDRIAL ANTIBODIES IN PATIENTS WITH PRIMARY BILE CHOLANGITIS AND ITS OUTCOME IN LIVER TRANSPLANTATION

Annals of Hepatology, 2021
Introduction: The presence of antimitochondrial antibodies has been described as a diagnostic criterion for primary biliary cholangitis. However, no studies have been established in the South American population to describe the prevalence of these ...
Andres Gomez Aldana, Monica Tapias, Jose De la Hoz, Juanita Leon, Jannet Lopez, Alvaro Lozada   +5 more
doaj   +1 more source

Unique DUOX2+ACE2+ small cholangiocytes are pathogenic targets for primary biliary cholangitis

Nature Communications, 2023
The aetiology of primary biliary cholangitis (PBC) remains unclear. Here, the authors find that the numbers of DUOX2^ + ACE2 ^+ small cholangiocytes in human and mouse livers are inversely associated with disease severity, and present data indicating ...
Xi Li, Yan Li, Jin-Tao Xiao, Huiwen Wang, Yan Guo, Xiuru Mao, P. Shi, Yanliang Hou, Xiao-Xun Zhang, Nan Zhao, Minghua Zheng, Yonghong He, Jingjing Ding, Ya Tan, Min Liao, Ling Li, Ying Peng, Xuan Li, Qiong-Jing Pan, Qiaoling Xie, Qiao Li, Jianwei Li, Ying Li, Zhe Chen, Yongxiu Huang, D. Assis, Shi-Ying Cai, J. Boyer, Xue-Quan Huang, Can-E Tang, Xiaowei Liu, Shi-Fang Peng, Jin Chai   +32 more
semanticscholar   +1 more source

Primary Biliary Cholangitis: an update on treatment. [PDF]

, 2019
Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is a chronic but progressive disease that, over many years, causes damage to bile ducts, leading to cholestasis and, in some patients, cirrhosis.
Mortimore, Gerri
core   +1 more source

Systemic sclerosis and primary biliary cholangitis : Longitudinal data to determine the outcomes

, 2023
Background: Several studies described the cross-sectional characteristics of systemic sclerosis patients and coexisting primary biliary cholangitis, but longitudinal prognostic data are lacking.
Bruni, Cosimo,, Smith, Vanessa, Novikov, Pavel, Ingegnoli, Francesca, Truchetet, Marie-Elise, Moiseev, Sergey,, Krasowska, Dorota,, Cuomo, Giovanna,, Ionescu, Ruxandra, Airò, Paolo,, Ingegnoli, Francesca,, Distler, Oliver,, Tofani, Lorenzo, Bellocchi, Chiara,, Braun-Moscovici, Yolanda,, Groseanu, Laura,, Iannone, Florenzo, Rednic, Simona, Ionescu, Ruxandra,, Allanore, Yannick, Krusche, Martin,, Szabo, Iulia,, Walker, Ulrich A.,, Matucci-Cerinic, Marco,, Walker, Ulrich A., Moiseev, Sergey, Andréasson, Kristofer, De Langhe, Ellen, Cuomo, Giovanna, Allanore, Yannick,, Matucci-Cerinic, Marco, Walker, Ulrich A, Codullo, Veronica,, Balbir-Gurman, Alexandra, Lund University., Novikov, Pavel,, Bellocchi, Chiara, Manolaraki, Chrysoula,, Krusche, Martin, Krasowska, Dorota, Beretta, Lorenzo,, Truchetet, Marie Elise,, Iannone, Florenzo,, Airò, Paolo, Groseanu, Laura, Rosato, Edoardo, Hachulla, Eric,, Andréasson, Kristofer,, Lepri, Gemma, Bruni, Cosimo, Bellando-Randone, Silvia, Beretta, Lorenzo, Rednic, Simona,, Balbir-Gurman, Alexandra,, Hachulla, Eric, Codullo, Veronica, Smith, Vanessa,, Truchetet, Marie Elise, Distler, Oliver, Braun-Moscovici, Yolanda, Garzanova, Liudmila,, Manolaraki, Chrysoula, Garzanova, Liudmila, Guiducci, Serena, Szabo, Iulia, De Langhe, Ellen,   +65 more
core   +3 more sources

Guidelines on the Diagnosis and Management of Primary Biliary Cholangitis (2021)

Journal of Clinical and Translational Hepatology, 2023
In 2015, the Chinese Society of Hepatology and the Chinese Society of Gastroenterology published a consensus on primary biliary cholangitis (PBC). In the past years, numerous clinical studies have been published in the field of PBC. To guide the clinical
H. You, Wei-Jia Duan, Shu-Xiang Li, Tingting Lv, Sha Chen, Lun-Gen Lu, Xiong Ma, Ying Han, Yue Nan, Xiao-Yuan Xu, Z. Duan, Lai Wei, J. Jia, H. Zhuang   +13 more
semanticscholar   +1 more source