Results 101 to 110 of about 11,978,501 (365)
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Mechanisms and disease consequences of nonalcoholic fatty liver disease
Cell, 2021 R. Loomba, S. Friedman, G. Shulman
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
STUDIES ON THE ELECTROCARDIOGRAM IN LIVER DISEASE VECTORCARDIOGRAM IN LIVER DISEASE
Nihon Naika Gakkai Zasshi, 1964 肝疾患と心臓との関係を究明するため,肝疾患患者のベクトル心電図を木村法(148例), Frank法(22例)により撮影し,これらと肝機能,血清蛋白,血清電解質および心電図を比較検討した. QRS, T環最大ベクトルの大きさは急性肝炎,慢性肝炎,肝硬変症の順に小となり, QRS-T夾角は逆の順に大となる.また, QRS, T環最大ベクトルの大きさは,肝機能障害の強くなるにつれ,また血清蛋白のうちγ-globulinの増加群で小となる.この関係はとくにT環で著しい.
openaire +3 more sources
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease [PDF]
, 2019 Gordon I. Smith +13 more
openalex +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Clinical value of liver ultrasound for the diagnosis of nonalcoholic fatty liver disease in overweight and obese patients [PDF]
, 2015 Fernando Bril +10 more
openalex +1 more source
Secondary bile acids improve risk prediction for non‐invasive identification of mild liver fibrosis in nonalcoholic fatty liver disease [PDF]
, 2023 A‐Na Liu +17 more
openalex +1 more source