Results 71 to 80 of about 11,978,501 (365)

Mortality in Biopsy-Confirmed Nonalcoholic Fatty Liver Disease

Gut, 2020
Objective Population-based data are lacking regarding the risk of overall and cause-specific mortality across the complete histological spectrum of non-alcoholic fatty liver disease (NAFLD).
Tracey G. Simon, B. Roelstraete, H. Khalili, H. Hagström, J. Ludvigsson   +4 more
semanticscholar   +1 more source

Alcoholic Liver Disease

Medical Clinics of North America, 1989
Alcohol has been implicated in the genesis of liver disease for centuries. Significant progress has been made in our understanding of the pathogenesis of ALD. It is now apparent that both the consumption and the metabolism of alcohol promote the production of inflammatory mediators (cytokines) that result in hepatotoxicity and fibrogenesis.
openaire   +3 more sources

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Risk factor analysis and predictive model construction of lean MAFLD: a cross-sectional study of a health check-up population in China

European Journal of Medical Research
Aim Cardiovascular disease morbidity and mortality rates are high in patients with metabolic dysfunction-associated fatty liver disease (MAFLD). The objective of this study was to analyze the risk factors and differences between lean MAFLD and overweight
Ruya Zhu, Caicai Xu, Suwen Jiang, Jianping Xia, Boming Wu, Sijia Zhang, Jing Zhou, Hongliang Liu, Hongshan Li, Jianjun Lou   +9 more
doaj   +1 more source

A novel imaging index for predicting adverse progression in acute-on-chronic liver failure related to hepatitis B virus: the low erector spine index

BMC Gastroenterology, 2023
Background It is widely known that muscle mass influences the outcomes of many chronic diseases. Erector spine mass is a convenient parameter obtained from routine abdominal computed tomography (CT).
Chao Zhou, Yuan Liu, Xiaoxiao Liang, Ning Zhang, Tingting He, Jingjing Zhang, Jin Zhang, Shuangnan Fu, Xin Li, Pengcheng Liu, Tianyi Zhang, Man Gong   +11 more
doaj   +1 more source

Non-Alcoholic Fatty Liver Disease in Lean and Non-Obese Individuals: Current and Future Challenges [PDF]

, 2021
Mohammad Shafi Kuchay, José Ignacio Martínez‐Montoro, Narendra S. Choudhary, José Carlos Fernández‐García, Bruno Ramos‐Molina   +4 more
openalex   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Impact of SARS-CoV-2 infection on liver disease

Advances in Laboratory Medicine, 2022
Abnormal liver biochemistry is not a rare finding in the context of SARS-CoV-2 infection, regardless of patients having pre-existing chronic disease or ...
Salgüero Fernández Sergio, Gabriel Medina Pablo, Almería Lafuente Alejandro, Ballesteros Vizoso María Antonieta, Zamora Trillo Angielys, Casals Mercadal Gregori, Solé Enrech Gemma, Lalana Garcés Marta, Guerra Ruiz Armando R., Ortiz Pastor Oihana, Morales Ruiz Manuel   +10 more
doaj   +1 more source

Liver physiology and liver diseases in the elderly

World Journal of Gastroenterology, 2013
The liver experiences various changes with aging that could affect clinical characteristics and outcomes in patients with liver diseases. Both liver volume and blood flow decrease significantly with age. These changes and decreased cytochrome P450 activity can affect drug metabolism, increasing susceptibility to drug-induced liver injury.
Kazuto, Tajiri, Yukihiro, Shimizu
openaire   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source