Results 81 to 90 of about 1,037,687 (337)

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

FEBS Letters, EarlyView.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva, Marcio Vinicius Bertacine Dias   +1 more
wiley   +1 more source

Development of a decision support tool to facilitate primary care management of patients with abnormal liver function tests without clinically apparent liver disease [HTA03/38/02]. Abnormal Liver Function Investigations Evaluation (ALFIE) [PDF]

, 2007
Liver function tests (LFTs) are routinely performed in primary care, and are often the gateway to further invasive and/or expensive investigations.
A Desgagne, AA Montgomery, AD Morris, AS Detsky, C Van Walraven, D Steinke, David McLernon, Douglas Steinke, DS Pratt, DT Steinke, DW Hosmer, FA Kerr, Frank M Sullivan, HC Kim, HT Sorensen, J Smith, JMM Evans, John F Dillon, KM Anderson, M Campbell, M Duh, M Futatsuka, OO Aalen, P McLone, P Roderick, P Sherwood, Paul Roderick, Peter T Donnan, PT Donnan, PT Donnan, PT Donnan, S Bellentani, Stephen Ryder, TK Gandhi, TP Almdal, William Rosenberg   +35 more
core   +7 more sources

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

ncRNA-mediated SOX4 overexpression correlates with unfavorable outcomes and immune infiltration in hepatocellular carcinoma

BMC Gastroenterology
Background The activity and number of immune cells in the tumor microenvironment are closely related to the overall survival of patients with hepatocellular carcinoma (HCC).
Jing Li, Xinfeng Sun, Minling Lv, Zhiyi Han, Xin Zhong, Wei Zhang, Rui Hu, Wenxing Feng, Mengqing Ma, Qi Huang, Xiaozhou Zhou   +10 more
doaj   +1 more source

Autoimmune hepatitis and overlap syndrome among Alaska Native people: Prevalence, clinical characteristics, and remission

JGH Open, 2023
Background and Aim High autoimmune hepatitis (AIH) and overlap syndrome (OS) prevalence have been previously documented among Alaska Native people. The purpose of this project is to report changes in AIH/OS prevalence over time, clinical characteristics,
Janet M. Johnston, Brian McMahon, Lisa Townshend‐Bulson, Julia Plotnik, Paarth Jain, Meggan Judge, Wileina Rhodes, Chriss Homan   +7 more
doaj   +1 more source

Pathogenesis of non-alcoholic fatty liver disease [PDF]

, 2009
Non-alcoholic fatty liver disease (NAFLD) represents a spectrum of disease ranging from hepatocellular steatosis through steatohepatitis to fibrosis and irreversible cirrhosis.
Abdelmalek, Adams, Adams, Aithal, Albanis, Andrews, Ayabe, Balkau, Bedogni, Belfort, Berg, Browning, Bugianesi, Cai, Chalasani, Charlton, Charlton, Chen, Chitturi, Clark, Clouston, Crespo, Davila, Day, Dixon, Donnelly, Dufour, Ekstedt, Feldstein, Franzese, Friedman, Gomez-Dominguez, Guo, Haukeland, Henderson, Hocking, Huang, Hudgins, Hui, Hyogo, Iltz, Iredale, J. K. Dowman, J.W. Tomlinson, Jou, Kammoun, Kaser, Kathirvel, Konopelska, Kugelmas, Lago, Lemoine, Lewis, Li, Lindor, Loguercio, Lord, Lutchman, Machado, Mantzoros, Marrero, Matarese, Miele, Namikawa, Nelson, Neuschwander-Tetri, Oakley, Okamoto, Olufadi, P.N. Newsome, Petta, Pikarsky, Pinzani, Postic, Preiss, P  rez-Carreras, Reynolds, Rockall, Ron, Roskams, Roskams, Sanyal, Satapathy, Saxena, Seki, Sell, Sermasathanasawadi, Solga, Svegliati-Baroni, Taniguchi, Tarantino, Tominaga, Tomita, Uygun, Valenti, van der Poorten, Van Hul, Vuppalanchi, Walker, Weltman, Whitehead, Wigg, Wilfred de Alwis, Xia, Xu, Yamaguchi, Yesilova, Yoneda, Yuan   +108 more
core   +2 more sources

Immunoglobulin A and liver diseases [PDF]

Journal of Gastroenterology, 2017
Immunoglobulin A (IgA) is a major immunoglobulin isotype in the gut and plays a role in maintenance of gut homeostasis. Secretory IgA (SIgA) has multiple functions in the gut, such as to regulate microbiota composition, to protect intestinal epithelium from pathogenic microorganisms, and to help for immune-system development.
Tatsuo Inamine, Bernd Schnabl
openaire   +3 more sources

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Real-world systemic sequential therapy with regorafenib for recurrent hepatocellular carcinoma: analysis of 93 cases from a single center

BMC Gastroenterology, 2023
Background Regorafenib is an oral multikinase inhibitor and became the first second-line systemic treatment for hepatocellular carcinoma (HCC) following the phase III RESORCE trial.
Qingwei Zhu, Wei Rao, Junyu Huo, Zixiang Li, Song Wang, Wensheng Qiu, Ge Guan, Yang Xin, Ning Fan, Jinzhen Cai, Liqun Wu   +10 more
doaj   +1 more source

Tropical liver disease [PDF]

Medicine, 2007
The liver is frequently involved in infections that are prevalent in different regions of the tropics, and chronic liver disease, sometimes with multiple aetiological explanations, is an important cause of early morbidity and mortality. This article describes some hepatic and biliary problems that are seen in the tropics, or which may be imported from ...
Nicholas J. Beeching, Nicholas J. Beeching, Anuradha S Dassanayake, Anuradha S Dassanayake   +3 more
openaire   +1 more source