Results 1 to 10 of about 651,421 (240)
Autophagy in non-alcoholic fatty liver disease and alcoholic liver disease [PDF]
Liver Research, 2018 Autophagy is an evolutionarily conserved intracellular degradative function that is important for liver homeostasis. Accumulating evidence suggests that autophagy is deregulated during the progression and development of alcoholic and non-alcoholic liver ...
Bilon Khambu +4 more
doaj +3 more sources
Role and Mechanisms of Mitophagy in Liver Diseases
Cells, 2020 The mitochondrion is an organelle that plays a vital role in the regulation of hepatic cellular redox, lipid metabolism, and cell death. Mitochondrial dysfunction is associated with both acute and chronic liver diseases with emerging evidence indicating ...
Xiaowen Ma +3 more
doaj +2 more sources
Frontiers in Medicine, 2022 Background:Non-alcoholic fatty liver disease (NAFLD) is a global health problem affecting more than a quarter of the entire adult population. Both monocytes and high-density lipoprotein cholesterol (HDL-C) were found to participate in the progression of ...
Liping Wang +8 more
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Subclinical versus advanced forms of alcohol-related liver disease: Need for early detection [PDF]
Clinical and Molecular Hepatology, 2023 Alcohol-related liver disease (ALD) consists of a wide spectrum of clinical manifestations and pathological features, ranging from asymptomatic patients to decompensated cirrhosis and hepatocellular carcinoma.
Concepción Gómez-Medina +3 more
doaj +1 more source
Current Opinion in Gastroenterology, 2000 Important mechanisms responsible for alcohol-induced liver injury include mitochondrial damage and loss of ATP, formation of acetaldehyde-and other aldehyde-protein adducts, release of reactive oxygen species (ROS) from mitochondrial electron transfer chain, CYP2E1 , and activated Kupffer cells (KCs); weakening of antioxidant defense systems; and ...
L, Lumeng, D W, Crabb
openaire +5 more sources
Oral Pathogenic Bacteria and the Oral–Gut–Liver Axis: A New Understanding of Chronic Liver Diseases
Diagnostics, 2023 Liver diseases have long been a prevalent cause of morbidity and mortality, and their development and progression involve multiple vital organs throughout the body.
Yumeng Lei +6 more
doaj +1 more source
Advancements in the treatment of non-alcoholic fatty liver disease (NAFLD)
Frontiers in Endocrinology, 2023 Non-alcoholic fatty liver disease (NAFLD) is a series of diseases, involving excessive lipid deposition in the liver and is often accompanied by obesity, diabetes, dyslipidemia, abnormal blood pressure, and other metabolic disorders.
L. Rong +6 more
semanticscholar +1 more source
Endoplasmic reticulum stress and autophagy dysregulation in alcoholic and non-alcoholic liver diseases [PDF]
Clinical and Molecular Hepatology, 2020 Alcoholic and non-alcoholic liver diseases begin from an imbalance in lipid metabolism in hepatocytes as the earliest response. Both liver diseases share common disease features and stages (i.e., steatosis, hepatitis, cirrhosis, and hepatocellular ...
Yun Seok Kim, Sang Geon Kim
doaj +1 more source
Endoplasmic Reticulum Stress in Liver Diseases.
Hepatology, 2022 The endoplasmic reticulum (ER) is an intracellular organelle that fosters the correct folding of linear polypeptides and proteins, a process tightly governed by the ER-resident enzymes and chaperones.
Amir Ajoolabady +6 more
semanticscholar +1 more source
Epidemiology of non-alcoholic and alcoholic fatty liver diseases.
Translational Gastroenterology and Hepatology, 2020 Liver diseases are fast emerging as global health priorities. Fatty liver is described in the setting of non-alcoholic fatty liver disease (NAFLD) as well as alcoholic liver disease (ALD), the pathogenesis of excess fat being different in the two ...
Souveek Mitra, Arka De, A. Chowdhury
semanticscholar +1 more source