Results 191 to 200 of about 201,743 (308)

Non-alcoholic fatty liver disease as a predictor of atrial fibrillation recurrence following ablation: a retrospective study. [PDF]

Cardiovasc Diagn Ther
Wang Z, Luo F, Zhang Y, Zhai Y, Chen X, Sun L, Chen Y.   +6 more
europepmc   +1 more source

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

A Long‐Acting and Sustained‐Release Poly (L‐Lactic Acid) Microsphere System Containing Naringin: Fabrication and In Vitro Bone Modification

Advanced Materials Interfaces, EarlyView.
ABSTRACT Poly (L‐lactic acid) (PLLA) is a biocompatible and safe polymer, making it an ideal material for fabricating microspheres for drug delivery. In this study, naringin, which a role in bone modification, is used as the active pharmaceutical ingredient, and PLLA is employed as the drug carrier to fabricate naringin‐loaded PLLA microspheres ...
Jingyuan Cui, Zhe Zhang, Dong Zhou, Lixin Zhang, Yulin Li   +4 more
wiley   +1 more source

Comparative analysis of autophagy and apoptosis pathways in viral and alcoholic cirrhosis: An immunohistochemical study. [PDF]

Saudi Med J
Demircan G, Berk S, Karayilan D, Ozgur BT, Ketenci S, Elbegi I, Karpuz V, Yavuz M, Midi A, Akin D.   +9 more
europepmc   +1 more source

Multifunctional Small Intestinal Submucosa Mesh for Scarless Abdominal Wall Defect Repair

Advanced Materials Interfaces, EarlyView.
a) Schematic illustration of the SIS/PCA/Mg mesh preparation. b) Schematic illustration of the repair of full‐thickness abdominal wall defects by multifunctional and degradable SIS/PCA/Mg mesh. ABSTRACT Decellularized small intestinal submucosa (SIS) mesh used for the treatment of abdominal wall defects often suffers from a high risk of recurrence due ...
Fuxin Tang, Zehui Hou, Haonan Huang, Xingxing Xie, Shuang Chen, Wenchang Gan, Ning Ma, Taicheng Zhou   +7 more
wiley   +1 more source

Liver immunology: new insights from cutting-edge technologies. [PDF]

Cell Mol Immunol
Guillot A, Gao B.
europepmc   +1 more source

Implantable Microarray Patch: Engineering at the Nano and Macro Scale for Sustained Therapeutic Release via Synthetic Biodegradable Polymers

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
This review focuses on the application of synthetic biodegradable microarray patches (MAPs) in sustained drug delivery. Compared to conventional MAPs which release drugs into the skin in an immediate manner, these implantable MAPs release drugs into skin microcirculation gradually as the biodegradable polymers degrade, thus offering sustained release ...
Li Zhao, Akmal Hidayat Bin Sabri, Mary B. McGuckin, Linlin Li, Zihao Wang, Eneko Larrañeta, Ryan F. Donnelly   +6 more
wiley   +1 more source

Multiplexed Luminal Tissue Constructs with Reconfigurable Barriers for Dynamic Modeling of Multi‐Tissue Interactions

Advanced Materials Technologies, EarlyView.
This study describes the fabrication of arrays of luminal tissue constructs for 3D luminal tissue modeling. An oil or media‐filled reservoir between constructs serves as a liquid barrier or bridge to regulate communication between lumens within the array for modeling multi‐tissue interactions in vitro. Abstract Cell‐lined luminal structures are crucial
Mouhita Humayun, José A. Jiménez‐Torres, Chao Li, Jose M. Ayuso, Karina Lugo‐Cintron, Joseph Ulbrich, Benjamin Myers, Sheena C. Kerr, Adeel Ahmed, David J. Beebe   +9 more
wiley   +1 more source

Low Alanine Aminotransferase Levels in Alcohol Consuming Male Subjects, Carriers of the Common ALDH2 Deficient Variant, ALDH2*2. [PDF]

Hepatol Res
Seike T, Chen CH, Mizukoshi E, Mochly-Rosen D.   +3 more
europepmc   +1 more source

Smart Sampling Capsule for Capture and Detection of Enteric Pathogens in the Small Intestine

Advanced Materials Technologies, EarlyView.
An ingestible smart sampling capsule for capturing asymptomatic enteric pathogens at their primary sites of interaction within the small intestine. This capability enables non‐invasive detection of early pathogen colonization within the gut environment prior to fecal shedding, providing a robust approach for pathogen surveillance and microbiome studies.
Akshay Krishnakumar, Devendra Sarnaik, Nicholas L. F. Gallina, Robyn R. McCain, Christa Crain, Arun K. Bhunia, Rahim Rahimi   +6 more
wiley   +1 more source