Results 1 to 10 of about 634,838 (206)

Acute Liver Failure

JAAPA
ABSTRACT Acute liver failure, commonly caused by acetaminophen overdose, is associated with numerous systemic complications including cerebral edema, hypotension, acute kidney injury, and infection. Management is primarily supportive, with an emphasis on excellent neurocritical care.
Girish V, Royer A, John S.
europepmc   +7 more sources

Acute liver failure [PDF]

The Lancet, 2020
Acute liver failure is a rare syndrome and is primarily caused by paracetamol toxicity in developed nations. Survival for patients with acute liver failure has steadily improved over the last few decades from approximately 20% to greater than 60%. This marked improvement in survival has been due to a combination of improvements in medical practice and ...
Sandro, Vento, Francesca, Cainelli
  +9 more sources

The role of RIPK1 mediated cell death in acute on chronic liver failure

Cell Death and Disease, 2021
Acute-on-chronic liver failure (ACLF) is characterized predominantly by non-apoptotic forms of hepatocyte cell death. Necroptosis is a form of programmed lytic cell death in which receptor interacting protein kinase (RIPK) 1, RIPK3 and phosphorylated ...
Takayuki Kondo, Stewart Macdonald, Cornelius Engelmann, Abeba Habtesion, Jane Macnaughtan, Gautam Mehta, Rajeshwar P. Mookerjee, Nathan Davies, Marco Pavesi, Richard Moreau, Paolo Angeli, Vicente Arroyo, Fausto Andreola, Rajiv Jalan   +13 more
doaj   +1 more source

Extracellular vesicles as potential biomarkers and treatment options for liver failure: A systematic review up to March 2022

Frontiers in Immunology, 2023
IntroductionExtracellular vesicles (EVs) carrying functional cargoes are emerging as biomarkers and treatment strategies in multiple liver diseases. Nevertheless, the potential of EVs in liver failure remains indistinct.
Wang Lu, Wang Lu, Huixin Tang, Huixin Tang, Shanshan Li, Shanshan Li, Li Bai, Li Bai, Yu Chen, Yu Chen   +9 more
doaj   +1 more source

Albumin Lipidomics Reveals Meaningful Compositional Changes in Advanced Cirrhosis and Its Potential to Promote Inflammation Resolution

Hepatology Communications, 2022
Albumin infusions are therapeutically used to revert hypoalbuminemia and to replace the extensively oxidized albumin molecule circulating in patients with acutely decompensated (AD) cirrhosis.
Mireia Casulleras, Roger Flores‐Costa, Marta Duran‐Güell, Ingrid W. Zhang, Cristina López‐Vicario, Anna Curto, Javier Fernández, Vicente Arroyo, Joan Clària   +8 more
doaj   +1 more source

Increased INR Values Predict Accelerating Deterioration and High Short-Term Mortality Among Patients Hospitalized With Cirrhosis or Advanced Fibrosis

Frontiers in Medicine, 2021
Background and Objective: An increase in the international normalized ratio (INR) is associated with increased mortality in patients with cirrhosis and other chronic liver diseases, while little is known about the quantitative relationship.
Ying Wang, Ying Wang, Fuchen Dong, Fuchen Dong, Shuning Sun, Shuning Sun, Xianbo Wang, Xianbo Wang, Xin Zheng, Xin Zheng, Yan Huang, Yan Huang, Beiling Li, Beiling Li, Yanhang Gao, Yanhang Gao, Zhiping Qian, Zhiping Qian, Feng Liu, Feng Liu, Xiaobo Lu, Xiaobo Lu, Junping Liu, Junping Liu, Haotang Ren, Haotang Ren, Yubao Zheng, Yubao Zheng, Huadong Yan, Huadong Yan, Guohong Deng, Guohong Deng, Liang Qiao, Liang Qiao, Yan Zhang, Yan Zhang, Wenyi Gu, Wenyi Gu, Xiaomei Xiang, Xiaomei Xiang, Yi Zhou, Yi Zhou, Baoyan Xu, Baoyan Xu, Yixin Hou, Yixin Hou, Qun Zhang, Qun Zhang, Yan Xiong, Yan Xiong, Congcong Zou, Congcong Zou, Jun Chen, Jun Chen, Zebing Huang, Zebing Huang, Xiuhua Jiang, Xiuhua Jiang, Tingting Qi, Tingting Qi, Sen Luo, Sen Luo, Yuanyuan Chen, Yuanyuan Chen, Na Gao, Na Gao, Chunyan Liu, Chunyan Liu, Wei Yuan, Wei Yuan, Xue Mei, Xue Mei, Jing Li, Jing Li, Tao Li, Tao Li, Rongjiong Zheng, Rongjiong Zheng, Xinyi Zhou, Xinyi Zhou, Weituo Zhang, Weituo Zhang, Hai Li, Hai Li, Zhongji Meng, Zhongji Meng   +85 more
doaj   +1 more source

Study on the Relationship between the Levels of Trace Elements and Vitamins in Peripheral Blood of Patients with End-stage Liver Disease and the Etiology and Severity of Disease [PDF]

Zhongguo quanke yixue, 2022
Background Patients with end-stage liver disease such as liver cirrhosis and acute-on-chronic liver failure (ACLF) often have abnormal intake or absorption of trace elements and vitamins, but the relevant tests have not been popularized in clinic, the ...
Ming KONG, Manman XU, Yu CHEN
doaj   +1 more source

Acute-On-Chronic Liver Failure Defined by Asian Pacific Association for the Study of the Liver Should Include Decompensated Cirrhosis

Frontiers in Medicine, 2021
Background and Aims: Acute-on-chronic liver failure (ACLF) is an acute deterioration of chronic liver disease with high short-term mortality. The inclusion or exclusion of previously decompensated cirrhosis (DC) in the diagnostic criteria of ACLF defined
Manman Xu, Manman Xu, Ming Kong, Ming Kong, Pengfei Yu, Pengfei Yu, Yingying Cao, Fang Liu, Bing Zhu, Yizhi Zhang, Yizhi Zhang, Wang Lu, Wang Lu, Huaibin Zou, Huaibin Zou, Shaoli You, Shaojie Xin, Zhongping Duan, Zhongping Duan, Tao Han, Yu Chen, Yu Chen   +21 more
doaj   +1 more source

Acute liver failure [PDF]

Postgraduate Medical Journal, 1997
Abstract Acute liver failure is a complex multisystemic illness that evolves quickly after a catastrophic insult to the liver leading to the development of encephalopathy. The underlying aetiology and the pace of progression strongly influence the clinical course.
openaire   +5 more sources

M2-like macrophages exert hepatoprotection in acute-on-chronic liver failure through inhibiting necroptosis-S100A9-necroinflammation axis

Cell Death and Disease, 2021
Necroptosis has emerged as a novel and crucial player in acute and chronic liver diseases. Necroptotic cells lead to the release of DAMPs including S100A9, followed by the development of necroinflammation.
Li Bai, Ming Kong, Zhongping Duan, Shuang Liu, Sujun Zheng, Yu Chen   +5 more
doaj   +1 more source