Results 11 to 20 of about 865,411 (286)

Analysis of serum inflammatory mediators identifies unique dynamic networks associated with death and spontaneous survival in pediatric acute liver failure. [PDF]

PLoS ONE, 2013
Tools to predict death or spontaneous survival are necessary to inform liver transplantation (LTx) decisions in pediatric acute liver failure (PALF), but such tools are not available.
Nabil Azhar, Cordelia Ziraldo, Derek Barclay, David A Rudnick, Robert H Squires, Yoram Vodovotz, Pediatric Acute Liver Failure Study Group   +6 more
doaj   +1 more source

Procalcitonin Identifies Cell Injury, Not Bacterial Infection, in Acute Liver Failure. [PDF]

PLoS ONE, 2015
Because acute liver failure (ALF) patients share many clinical features with severe sepsis and septic shock, identifying bacterial infection clinically in ALF patients is challenging.
Jody A Rule, Linda S Hynan, Nahid Attar, Corron Sanders, William J Korzun, William M Lee, Acute Liver Failure Study Group   +6 more
doaj   +1 more source

Detection of Ophthalmic Acid in Serum from Acetaminophen-Induced Acute Liver Failure Patients Is More Frequent in Non-Survivors. [PDF]

PLoS ONE, 2015
Acetaminophen (APAP) hepatotoxicity is related to the formation of N-acetyl-p-benzoquinone imine (NAPQI), which is detoxified through conjugation with reduced glutathione (GSH).
Gurnit Kaur, Elaine M Leslie, Holly Tillman, William M Lee, Diane P Swanlund, Constantine J Karvellas, US Acute Liver Failure Study Group   +6 more
doaj   +1 more source

EASL Clinical Practice Guidelines on acute-on-chronic liver failure.

Journal of Hepatology, 2023
Acute-on-chronic liver failure (ACLF) which has been recently described (2013), is a severe form of acutely decompensated cirrhosis characterized by the existence of organ system failure(s) and high risk of short-term death.
R. Moreau, M. Tonon, A. Krag, P. Angeli, M. Berenguer, A. Berzigotti, Javier Fernández, C. Francoz, T. Gustot, R. Jalan, M. Papp, J. Trebicka   +11 more
semanticscholar   +1 more source

Acute liver failure [PDF]

Postgraduate Medical Journal, 1997
Abstract Acute liver failure is a complex multisystemic illness that evolves quickly after a catastrophic insult to the liver leading to the development of encephalopathy. The underlying aetiology and the pace of progression strongly influence the clinical course.
openaire   +5 more sources

Acute Liver Failure Guidelines

American Journal of Gastroenterology, 2023
Acute liver failure (ALF) is a rare, acute, potentially reversible condition resulting in severe liver impairment and rapid clinical deterioration in patients without preexisting liver disease.
Alexandra Shingina, N. Mukhtar, Jamilé Wakim-Fleming, S. Alqahtani, R. Wong, B. Limketkai, Anne Larson, Lafaine Grant   +7 more
semanticscholar   +1 more source

Future Directions in Acute Liver Failure

Hepatology, 2023
Acute liver failure (ALF) describes a clinical syndrome of rapid hepatocyte injury leading to liver failure manifested by coagulopathy and encephalopathy in the absence of pre-existing cirrhosis.
R. Stravitz, R. Fontana, C. Karvellas, Valerie Durkalski, B. McGuire, Jody A. Rule, S. Tujios, William M. Lee   +7 more
semanticscholar   +1 more source

Acute-on-chronic liver failure: Terminology, mechanisms and management

Clinical and Molecular Hepatology, 2023
Acute-on-chronic liver failure is an acute deterioration of liver function manifesting as jaundice and coagulopathy with the development of ascites, with a high probability of extrahepatic organ involvement and high 28-day mortality.
V. Br, S. Sarin
semanticscholar   +1 more source

Acute-on-Chronic Liver Failure Clinical Guidelines

American Journal of Gastroenterology, 2022
In patients with cirrhosis and chronic liver disease, acute-on-chronic liver failure is emerging as a major cause of mortality. These guidelines indicate the preferred approach to the management of patients with acute-on-chronic liver failure and ...
J. Bajaj, J. O’Leary, J. Lai, F. Wong, M. Long, R. Wong, P. Kamath   +6 more
semanticscholar   +1 more source

Management of Acute Liver Failure: Update 2022

Seminars in liver disease (Print), 2022
Abbreviated pathogenesis and clinical course of the acute liver failure syndrome. The pathogenesis and clinical course of the syndrome of acute liver failure (ALF) differs depending upon the etiology of the primary liver injury.
S. Tujios, R. Stravitz, William M. Lee
semanticscholar   +1 more source