Results 71 to 80 of about 1,119,883 (334)

Liver transplantation for late-onset presentations of acute liver failure in Wilson's disease: The UK experience over 2 decades

JHEP Reports, 2020
Background & Aims: Acute liver failure as the initial presentation of Wilson’s disease is usually associated with onset in childhood, adolescence or early adulthood.
Samuel Shribman, Gwilym Webb, Rhiannon Taylor, Thomas T. Warner, Adam Duckworth, Alexander Gimson, Achuth Shenoy, William Griffiths   +7 more
doaj   +1 more source

Prognostic markers in acute liver failure - Alpha feto protein

Archives of Medicine and Health Sciences, 2021
Background and Aim: Acute liver failure is associated with high mortality and only about 40% patients survive without liver transplantation. The available prognostic models failed to predict the outcome correctly.
P Gayathri, Smitha Krishnamoorthy, Subhash Chandra, M G K Pillai, Raviraj Menon, Mahesh Subramania Iyer   +5 more
doaj   +1 more source

Orthotopic liver transplantation for fulminant and subacute hepatic failure [PDF]

, 1988
Fulminant and subacute hepatitis are conditions characterized by rapid liver failure, which can lead to death in 80 to more than 95% of the cases with medical supportive care only.
Iwatsuki, S, Starzl, TE, Stieber, AC
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Systematic review of the global epidemiology of viral-induced acute liver failure

BMJ Open, 2020
Objectives The aetiology and burden of viral-induced acute liver failure remains unclear globally. It is important to understand the epidemiology of viral-induced ALF to plan for clinical case management and case prevention.Participants This systematic ...
Rudzani Muloiwa, Jenna Patterson, Hannah Sophia Hussey, Sheetal Silal, Liz Goddard, Mashiko Setshedi, Wendy Spearman, Gregory D Hussey, Benjamin M Kagina   +8 more
doaj   +1 more source

Factors Associated with Survival of Patients With Severe Acute-On-Chronic Liver Failure Before and After Liver Transplantation.

Gastroenterology, 2019
BACKGROUND & AIMS Liver transplantation for patients with acute-on-chronic liver failure (ACLF) with 3 or more failing organs (ACLF-3) is controversial. We compared liver waitlist mortality or removal according to model for end-stage liver disease (MELD)
V. Sundaram, R. Jalan, Tiffany Wu, M. Volk, S. Asrani, A. Klein, R. Wong   +6 more
semanticscholar   +1 more source

Guidelines for the Management of Adult Acute and Acute-on-Chronic Liver Failure in the ICU: Cardiovascular, Endocrine, Hematologic, Pulmonary, and Renal Considerations

Critical Care Medicine, 2020
Supplemental Digital Content is available in the text. Objectives: To develop evidence-based recommendations for clinicians caring for adults with acute or acute on chronic liver failure in the ICU.
R. Nanchal, R. Subramanian, C. Karvellas, S. Hollenberg, William J. Peppard, K. Singbartl, J. Truwit, A. AL-Khafaji, Alley Killian, Mustafa Alquraini, Khalil Alshammari, F. Alshamsi, E. Belley‐Cote, R. Cartin-Ceba, J. Dionne, D. Galusca, David T. Huang, R. Hyzy, Mats L. Junek, P. Kandiah, G. Kumar, R. Morgan, P. Morris, J. Olson, R. Sieracki, R. Steadman, B. Taylor, W. Alhazzani   +27 more
semanticscholar   +1 more source

A clinicopathological study of human liver allograft recipients harboring preformed IgG lymphocytotoxic antibodies [PDF]

, 1992
Twenty‐six adult patients with preformed IgG donor lymphocytotoxic antibodies received primary liver allografts under FK 506 immunosuppression. The effect of the crossmatch‐positive state on early graft function and on the immunopathological and ...
Batts, Bird, Busch, Cerilli, Demetris, Demetris, Demetris, Dempster, Donaldson, Eggink, Giles, Gordon, Gubernatis, Gugenheim, Gugenheim, Hanto, Houssin, Ito, Iwaki, Iwatsuki, Kakizoe, Kissmeyer-Nielsen, Knechtle, Okuno, Simpson, Snover, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Takaya, Takaya, Takaya, Terada, Terasaki, Todo, Weber, Williams   +40 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

NBAS mutations cause acute liver failure: when acetaminophen is not a culprit

Italian Journal of Pediatrics, 2017
Background Pediatric acute-liver-failure due to acetaminophen (APAP) administration at therapeutic dosage is rare, while viral infections and metabolic defects are the prevalent causes. Yet, as acetaminophen is routinely used in febrile illnesses, it may
Pier Luigi Calvo, Francesco Tandoi, Tobias B. Haak, Andrea Brunati, Michele Pinon, Dominic Dell Olio, Renato Romagnoli, Marco Spada   +7 more
doaj   +1 more source