Results 81 to 90 of about 1,119,883 (334)

Acute liver failure is regulated by MYC- and microbiome-dependent programs

Nature Medicine, 2020
Acute liver failure (ALF) is a fulminant complication of multiple etiologies, characterized by rapid hepatic destruction, multi-organ failure and mortality. ALF treatment is mainly limited to supportive care and liver transplantation. Here we utilize the
Aleksandra A. Kolodziejczyk, Sara Federici, N. Zmora, Gayatree Mohapatra, Mally Dori-Bachash, Shanni Hornstein, Avner Leshem, Debby Reuveni, E. Zigmond, A. Tobar, T. Salame, A. Harmelin, A. Shlomai, H. Shapiro, I. Amit, E. Elinav   +15 more
semanticscholar   +1 more source

Effects of hypothermia on brain glucose metabolism in acute liver failure: a H/C-nuclear magnetic resonance study [PDF]

, 2003
Mild hypothermia has a protective effect on brain edema and encephalopathy in both experimental and human acute liver failure. The goals of the present study were to examine the effects of mild hypothermia (35°C) on brain metabolic pathways using ...
Butterworth, Roger, Chatauret, Nicolas, Leibfritz, Dieter, Rose, Christopher, Zwingmann, Claudia   +4 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Liver Transplantation for Acute Liver Failure due to Mushroom Poisoning

The Turkish Journal of Gastroenterology
Background/Aims: Liver transplantation is a life-saving approach in some cases of mushroom poisoning, which is one of the important causes of acute liver failure. However, debate continues regarding the timing of liver transplantation.
Hayri Canbaz, Attila Bestemir, Sami Akbulut, Sezai Yilmaz, Yusuf Yavuz   +4 more
doaj   +1 more source

Liver Transplantation because of Acute Liver Failure due to Heme Arginate Overdose in a Patient with Acute Intermittent Porphyria

Case Reports in Gastroenterology, 2012
In acute attacks of acute intermittent porphyria, the mainstay of treatment is glucose and heme arginate administration. We present the case of a 58-year-old patient with acute liver failure requiring urgent liver transplantation after erroneous 6-fold ...
Pascal Frei, Elisabeth I. Minder, Natascia Corti, Beat Muellhaupt, Andreas Geier, Heiner Adams, Jean-Paul Dutertre, Alain Rudiger, Philipp Dutkowski, Marco Maggiorini, Christoph C. Ganter   +10 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

When the heart kills the liver: acute liver failure in congestive heart failure

European Journal of Medical Research, 2009
Congestive heart failure as a cause of acute liver failure is rarely documented with only a few cases. Although the pathophysiology is poorly understood, there is rising evidence, that low cardiac output with consecutive reduction in hepatic blood flow ...
Saner FH, Heuer M, Meyer M, Canbay A, Sotiropoulos GC, Radtke A, Treckmann J, Beckebaum S, Dohna-Schwake C, Oldedamink SW, Paul A   +10 more
doaj   +1 more source

Leukocytes, Systemic Inflammation and Immunopathology in Acute-on-Chronic Liver Failure

Cells, 2020
Acute-on-chronic liver failure (ACLF) is a complex syndrome that develops in patients with cirrhosis and is characterized by acute decompensation, organ failure(s) and high short-term mortality.
M. Casulleras, I. Zhang, C. López‐Vicario, J. Clària   +3 more
semanticscholar   +1 more source

Cause and timing of first allograft failure in orthotopic liver transplantation: A study of 177 consecutive patients [PDF]

, 1991
The cause and timing of first liver allograft failure was evaluated in 177 patients who underwent a second liver transplant between January 1984 and December 1988.
Busuttil, Carithers, Demetris, Demetris, Klintmalm, Krom, Kusne, Lerut, Maddrey, Polson, Ringe, Scharschmidt, Shaw, Starzl, Starzl, Starzl, Starzl, Starzl, Tzakis, van Thiel, Wozney, Yanaga, Yanaga   +22 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source