Results 91 to 100 of about 1,103,898 (314)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Decreased glutamate transporter (GLT-1) expression in frontal cortex of rats with acute liver failure [PDF]
, 1997 It has been suggested that reduced astrocytic uptake of neuronally released glutamate contributes to the pathogenesis of hepatic encephalopathy in acute liver failure.
Butterworth, Roger +4 more
core +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Journal of Lipid Research, 2005 We describe a method for the determination of the two major urinary metabolites of vitamin K as the methyl esters of their aglycone structures, 2-methyl-3-(3′-3′-carboxymethylpropyl)-1,4-naphthoquinone (5C-aglycone) and 2-methyl-3-(5′-carboxy-3′-methyl-2′
Dominic J. Harrington +5 more
doaj +1 more source
Renal and Hepatic Dysfunction in Malaria Patients in Minna, North Central Nigeria [PDF]
, 2009 Information on kidney and liver involvement in malaria in Africa is still very scanty. Kidney and liver functions were assessed in 70 malaria patients using serum levels of creatinine and urea and urinary protein levels as test indicators of kidney ...
Ogbadoyi, EO, Tsado, RD
core +1 more source
New Perspectives on Treatment of Hepatitis B Before and After Liver Transplantation [PDF]
, 2016 open5noThe hepatitis B virus (HBV) infects more than 260 million people globally, with increasing incidence, especially in developing countries.
Bortoluzzi, Ilaria +4 more
core +1 more source
A guide to reactive oxygen species in tumour hypoxia: measurement and therapeutic implications
Molecular Oncology, EarlyView.Hypoxia reshapes tumour redox landscapes by altering compartmental ROS production (mitochondria, NOX, ER, peroxisomes). Accurate interpretation requires oxygen‐contextualised measurement (live biosensors, chemical probes, EPR, LC–MS) and awareness of artefacts (reoxygenation, probe specificity).
Lina Hacker +3 more
wiley +1 more source
Correction to: Molecular pattern of lncRNAs in hepatocellular carcinoma
Journal of Experimental & Clinical Cancer Research, 2019 In the original publication of this article [1], the author’ affiliations need to be revised, because the first and second affiliations should combine as the same affiliation.
Haoming Mai +7 more
doaj +1 more source
Circulating microRNAs: promising candidates serving as novel biomarkers of acute hepatitis [PDF]
, 2012 Acute liver failure as life threatening condition comprises a difficult diagnostic situation to evaluate potential outcomes and therapeutic options. Thus, prognostic indicators are urgently needed for evaluation of progression of liver injury, clinical ...
Ali Canbay +5 more
core +2 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source