Results 1 to 10 of about 2,772,477 (308)

Matrix Metalloproteinase-7 Associated with Congestive Heart Failure in Peritoneal Dialysis Patients: A Prospective Cohort Study

Mediators of Inflammation, 2023
Background. Matrix metalloproteinase-7 (MMP7) is markedly expressed in patients with chronic kidney disease; its expression in dialysate and role in patients undergoing peritoneal dialysis (PD) have not been well established. Methods.
Zhiwen Xiao, Jianwei Tian, Fen Zhang, Xiaohong Zhong, Tingting Zhang, Zhixiu Yi, Yanhong Lin, Cong Yang, Dan Tang, Nirong Gong, Jun Ai   +10 more
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The Effects of 6 Common Antidiabetic Drugs on Anti-PD1 Immune Checkpoint Inhibitor in Tumor Treatment

Journal of Immunology Research, 2022
Diabetes and cancer are common diseases and are frequently diagnosed in the same individual. These patients need to take antidiabetic drugs while receiving antitumor drugs therapy. Recently, immunotherapy offers significant advances for cancer treatment.
Ze-Tao Zhan, Lu Liu, Ming-Zhen Cheng, Yi Gao, Wei-Jie Zhou   +4 more
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Complement C5a induces the generation of neutrophil extracellular traps by inhibiting mitochondrial STAT3 to promote the development of arterial thrombosis

Thrombosis Journal, 2022
Background Thrombotic events cannot be completely prevented by antithrombotics, implicating a therapeutic gap due to inflammation, a not yet sufficiently addressed mechanism.
Yejia Chen, Xiaobo Li, Xinxin Lin, Hongbin Liang, Xuewei Liu, Xinlu Zhang, Qiuxia Zhang, Fengyun Zhou, Chen Yu, Li Lei, Jiancheng Xiu   +10 more
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Metformin Collaborates with PINK1/Mfn2 Overexpression to Prevent Cardiac Injury by Improving Mitochondrial Function

Biology, 2023
Both mitochondrial quality control and energy metabolism are critical in maintaining the physiological function of cardiomyocytes. When damaged mitochondria fail to be repaired, cardiomyocytes initiate a process referred to as mitophagy to clear ...
Zhuang Ma, Zuheng Liu, Xudong Li, Hao Zhang, Dunzheng Han, Wenjun Xiong, Haobin Zhou, Xi Yang, Qingchun Zeng, Hao Ren, Dingli Xu   +10 more
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Programmable Synthetic Protein Circuits for the Identification and Suppression of Hepatocellular Carcinoma

Molecular Therapy: Oncolytics, 2020
Precisely identifying and killing tumor cells are diligent pursuits in oncotherapy. Synthesized gene circuits have emerged as an intelligent weapon to solve these problems.
Xu Han, Jiong Yang, Fanhong Zeng, Jun Weng, Yue Zhang, Qing Peng, Li Shen, Shigang Ding, Kaiyu Liu, Yi Gao   +9 more
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Engineered circular guide RNAs boost CRISPR/Cas12a- and CRISPR/Cas13d-based DNA and RNA editing

Genome Biology, 2023
Background The CRISPR/Cas12a and CRISPR/Cas13d systems are widely used for fundamental research and hold great potential for future clinical applications.
Xin Zhang, Xinlong Wang, Jie Lv, Hongxin Huang, Jiahong Wang, Ma Zhuo, Zhihong Tan, Guanjie Huang, Jiawei Liu, Yuchen Liu, Mengrao Li, Qixiao Lin, Lian Li, Shufeng Ma, Tao Huang, Ying Lin, Xiaoyang Zhao, Zhili Rong   +17 more
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SOX9 inactivation affects the proliferation and differentiation of human lung organoids

Stem Cell Research & Therapy, 2021
Background The regulation of the transcription factor sex-determining region Y-box transcription factor 9 (SOX9) in lung development has been described in mouse, but the same principles apply to human lung development is unknown due to a lack of ...
Lian Li, Jianqi Feng, Shanshan Zhao, Zhili Rong, Ying Lin   +4 more
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Hyperhomocysteinemia potentiates megakaryocyte differentiation and thrombopoiesis via GH-PI3K-Akt axis

Journal of Hematology & Oncology, 2023
Hyperhomocysteinemia (HHcy) is closely associated with thrombotic diseases such as myocardial infarction and stroke. Enhanced platelet activation was observed in animals and humans with HHcy.
Wenjing Lei, Zhuoliang Liu, Zhiyuan Su, Panpan Meng, Chun Zhou, Xiaomei Chen, Zheng Hu, An Xiao, Miaomiao Zhou, Liping Huang, Yiyue Zhang, Xianhui Qin, Junping Wang, Fengxin Zhu, Jing Nie   +14 more
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Dietary choline, via gut microbe- generated trimethylamine-N- oxide, aggravates chronic kidney disease-induced cardiac dysfunction by inhibiting hypoxia-induced factor 1α

Frontiers in Physiology, 2022
Chronic kidney disease (CKD) is a global public health problem that shortens lifespan primarily by increasing the risk of cardiovascular diseases. Trimethylamine-N-oxide (TMAO), a gut microbiota-derived toxin produced by metabolizing high-choline or ...
Feifei Xie, Xin Zhen, Xin Zhen, Zhuoliang Liu, Xiaomei Chen, Zhuanhua Liu, Miaomiao Zhou, Zhanmei Zhou, Zheng Hu, Fengxin Zhu, Qiaobing Huang, Lei Zhang, Jing Nie   +12 more
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Mitofusin 2 Participates in Mitophagy and Mitochondrial Fusion Against Angiotensin II-Induced Cardiomyocyte Injury

Frontiers in Physiology, 2019
BackgroundMitochondrial dynamics play a critical role in mitochondrial function. The mitofusin 2 (MFN2) gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion to maintain and operate the mitochondrial network.
Wenjun Xiong, Wenjun Xiong, Zhuang Ma, Zhuang Ma, Dongqi An, Dongqi An, Zuheng Liu, Zuheng Liu, Wanqiang Cai, Wanqiang Cai, Yujia Bai, Yujia Bai, Qiong Zhan, Qiong Zhan, Wenyan Lai, Wenyan Lai, Qingchun Zeng, Qingchun Zeng, Hao Ren, Hao Ren, Dingli Xu, Dingli Xu   +21 more
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