Results 11 to 20 of about 1,172,749 (303)

Hyperhomocysteinemia potentiates megakaryocyte differentiation and thrombopoiesis via GH-PI3K-Akt axis

Journal of Hematology & Oncology, 2023
Hyperhomocysteinemia (HHcy) is closely associated with thrombotic diseases such as myocardial infarction and stroke. Enhanced platelet activation was observed in animals and humans with HHcy.
Wenjing Lei, Zhuoliang Liu, Zhiyuan Su, Panpan Meng, Chun Zhou, Xiaomei Chen, Zheng Hu, An Xiao, Miaomiao Zhou, Liping Huang, Yiyue Zhang, Xianhui Qin, Junping Wang, Fengxin Zhu, Jing Nie   +14 more
doaj   +1 more source

Acute-on-Chronic Liver Failure: Definition, Diagnosis, and Clinical Characteristics [PDF]

, 2016
Acute-on-chronic liver failure (ACLF) is a recently recognized syndrome in cirrhosis characterized by acute decompensation (AD), organ failure(s), and high short-term mortality.
Arroyo, V, Fernandez, J, Garcia-Tsao, G, Gines, P, Jalan, R, Kamath, PS, Moreau, R, Nevens, F, Schnabl, B, To, U   +9 more
core   +1 more source

Dietary choline, via gut microbe- generated trimethylamine-N- oxide, aggravates chronic kidney disease-induced cardiac dysfunction by inhibiting hypoxia-induced factor 1α

Frontiers in Physiology, 2022
Chronic kidney disease (CKD) is a global public health problem that shortens lifespan primarily by increasing the risk of cardiovascular diseases. Trimethylamine-N-oxide (TMAO), a gut microbiota-derived toxin produced by metabolizing high-choline or ...
Feifei Xie, Xin Zhen, Xin Zhen, Zhuoliang Liu, Xiaomei Chen, Zhuanhua Liu, Miaomiao Zhou, Zhanmei Zhou, Zheng Hu, Fengxin Zhu, Qiaobing Huang, Lei Zhang, Jing Nie   +12 more
doaj   +1 more source

Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in acute lung injury to reduce pulmonary dysfunction (HARP-2) trial : study protocol for a randomized controlled trial [PDF]

, 2012
Acute lung injury (ALI) is a common devastating clinical syndrome characterized by life-threatening respiratory failure requiring mechanical ventilation and multiple organ failure.
A Mercat, AM Cheung, C Brun-Buisson, C Rossi, Cecilia M O’Kane, Christine McNally, Daniel F McAuley, DJ Kor, Excellence NIfHaC, F Gao Smith, Gavin D Perkins, GD Rubenfeld, GR Bernard, Grainne Crealey, Irish Critical Care Trials Group, John G Laffey, KF Schulz, LA Curtis, Lynn Murphy, M Shyamsundar, MA Matthay, Mark Cross, Michael Stevenson, MS Herridge, RG Brower, S Harvey, SE Erickson, T Craig, The ARDS Network investigators, The EuroQol Group, TR Craig, TW Felton   +31 more
core   +1 more source

Mitofusin 2 Participates in Mitophagy and Mitochondrial Fusion Against Angiotensin II-Induced Cardiomyocyte Injury

Frontiers in Physiology, 2019
BackgroundMitochondrial dynamics play a critical role in mitochondrial function. The mitofusin 2 (MFN2) gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion to maintain and operate the mitochondrial network.
Wenjun Xiong, Wenjun Xiong, Zhuang Ma, Zhuang Ma, Dongqi An, Dongqi An, Zuheng Liu, Zuheng Liu, Wanqiang Cai, Wanqiang Cai, Yujia Bai, Yujia Bai, Qiong Zhan, Qiong Zhan, Wenyan Lai, Wenyan Lai, Qingchun Zeng, Qingchun Zeng, Hao Ren, Hao Ren, Dingli Xu, Dingli Xu   +21 more
doaj   +1 more source

Critical care provision after colorectal cancer surgery [PDF]

, 2016
Background: Colorectal cancer (CRC) is the 2nd largest cause of cancer related mortality in the UK with 40 000 new patients being diagnosed each year. Complications of CRC surgery can occur in the perioperative period that leads to the requirement of ...
Dale, C.D., Kinsella, J., McLoone, P., Morrison, D., Puxty, K., Quasim, T., Sloan, B.   +6 more
core   +1 more source

Moderate-Intensity Exercise Affects Gut Microbiome Composition and Influences Cardiac Function in Myocardial Infarction Mice

Frontiers in Microbiology, 2017
Physical exercise is commonly regarded as protective against cardiovascular disease (CVD). Recent studies have reported that exercise alters the gut microbiota and that modification of the gut microbiota can influence cardiac function.
Zuheng Liu, Zuheng Liu, Hai-Yue Liu, Hai-Yue Liu, Haobin Zhou, Haobin Zhou, Qiong Zhan, Qiong Zhan, Wenyan Lai, Wenyan Lai, Qingchun Zeng, Qingchun Zeng, Hao Ren, Hao Ren, Dingli Xu, Dingli Xu   +15 more
doaj   +1 more source

When life comes to an end : lessons from microbial aging models [PDF]

, 2010
Aging of biological systems ultimately leads to death of the individual. In humans, organ failure as the result of functional impairments after stroke, cardio-vascular disease, tumor development, neurodegeneration and other diseases are certainly crucial
Osiewacz, Heinz D.
core   +1 more source

Statin therapy in critical illness : an international survey of intensive care physicians' opinions, attitudes and practice [PDF]

, 2012
Background Pleotropic effects of statins on inflammation are hypothesised to attenuate the severity of and possibly prevent the occurrence of the host inflammatory response to pathogen and infection-related acute organ failure.
Di Gangi, Stefania, Kruger, Peter S., McAuley, Danny F., Perkins, Gavin D., Scales, Damon C., Shankar-Hari, Manu, Terblanche, Marius   +6 more
core   +1 more source

Sirt1 Antisense Long Noncoding RNA Promotes Cardiomyocyte Proliferation by Enhancing the Stability of Sirt1

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Antisense long noncoding RNAs (lncRNAs) are single‐stranded RNAs that overlapped gene‐coding regions on the opposite DNA strand and play as critical regulators in cardiovascular diseases.
Bing Li, Yinlan Hu, Xinzhong Li, Guoqing Jin, Xiaoqiang Chen, Guojun Chen, Yanmei Chen, Senlin Huang, Wangjun Liao, Yulin Liao, Zhonghua Teng, Jianping Bin   +11 more
doaj   +1 more source