Results 101 to 110 of about 1,429,832 (378)

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

Prediction of liver disease in patients whose liver function tests have been checked in primary care : model development and validation using population-based observational cohorts [PDF]

, 2014
Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.Peer reviewedPublisher ...
Altman, Carstairs, Chambless, Collett, Craig, D'Agostino, Donnan, Donnan, Dorans, Evans, Fornasini, Goodwin, Hawkins, Kim, McLernon, McLernon, Moons, Morris, Pencina, Pratt, R Core Team, Roderick, Rubin, Rubin, Schalk, Sherwood, Siris, Sorensen, Steinke, Sterne, Steyerberg, Sullivan, Vickers, Vickers, Yuan   +34 more
core   +4 more sources

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source

Automated Unsupervised Segmentation of Liver Lesions in CT scans via Cahn-Hilliard Phase Separation [PDF]

arXiv, 2017
The segmentation of liver lesions is crucial for detection, diagnosis and monitoring progression of liver cancer. However, design of accurate automated methods remains challenging due to high noise in CT scans, low contrast between liver and lesions, as well as large lesion variability.
arxiv  

Kidney and Liver Predictors of Adults Hospitalized with COVID-19 Infection

COVID
SARS-CoV-2 damages not only the lungs, but also the liver and kidney. Most critically ill COVID-19 patients have liver and kidney dysfunctions. The early identification of patients with COVID-19 who will develop severe or critical disease symptoms is ...
Mariana Boulos, Moeen Sbeit, Maamoun Basheer, Guy Ben Arie, Yuval Mirkin, Nimer Assy   +5 more
doaj   +1 more source

Effect of microbial cell preparation on renal profile and liver function among type 2 diabetics: a randomized controlled trial [PDF]

, 2015
Background: The beneficial effect of probiotics on renal profile and liver function has been reported among patients with chronic kidney disease and fatty liver respectively.
Amin Ismail, Barakatun-Nisak Mohd-Yusof, Hazreen-Abd Majid, Nor-Azmi Kamaruddin, Somayyeh Firouzi   +4 more
core   +2 more sources

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Neural Network-Based Automatic Liver Tumor Segmentation With Random Forest-Based Candidate Filtering [PDF]

arXiv, 2017
We present a fully automatic method employing convolutional neural networks based on the 2D U-net architecture and random forest classifier to solve the automatic liver lesion segmentation problem of the ISBI 2017 Liver Tumor Segmentation Challenge (LiTS).
arxiv  

The effects of N-acetylcysteine on hepatic function during isoflurane anaesthesia for laparoscopic surgery patients

Indian Journal of Anaesthesia, 2011
Introduction: Although most general anaesthesia procedures are performed without any complications, volatile agents may have adverse effects on various living systems. This study aims to compare the antioxidant effects of isoflurane and N-acetylcysteine (
Serbülent Gökhan Beyaz, Birgul Yelken, Güngor Kanbak   +2 more
doaj   +1 more source

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

Molecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Elin Borgen, Cecilie Bendigtsen Schirmer, Bjørnar Gilje, Øystein Garred, Jon Lømo, Marius Stensland, Oddmund Nordgård, Ragnhild Sørum Falk, Randi R. Mathiesen, Hege G. Russnes, Jon Amund Kyte, Bjørn Naume   +13 more
wiley   +1 more source