Results 91 to 100 of about 4,185,241 (381)

The role of human cytochrome P450 2E1 in liver inflammation and fibrosis. [PDF]

, 2017
Cytochrome P450 2E1 (CYP2E1) plays an important role in alcohol and toxin metabolism by catalyzing the conversion of substrates into more polar metabolites and producing reactive oxygen species.
Brenner, David A, Davidson, Nicholas O, Dennis, Edward A, Hu, Ronglin, Karin, Gabriel, Kisseleva, Tatiana, Koyama, Yukinori, Liang, Shuang, Ma, Hsiao-Yen, Quehenberger, Oswald, Sun, Mengxi, Xu, Jun   +11 more
core   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Mechanisms of the TGF-β1/Smad3-signaling pathway in gender differences in alcoholic liver fibrosis

Journal of Physiological Sciences
The TGF-β1/Smad3-signaling pathway and gender differences were investigated in alcoholic liver fibrosis. Mice were divided into female normal, female model, male normal, and male model groups.
Xiaomin Hong, Sanqiang Li, Renli Luo, Mengli Yang, Junfei Wu, Shuning Chen, Siyu Zhu   +6 more
doaj   +1 more source

Increased Expression of Cytotoxic T-Lymphocyte-Associated Protein 4 by T Cells, Induced by B7 in Sera, Reduces Adaptive Immunity in Patients With Acute Liver Failure. [PDF]

, 2017
BACKGROUND & AIMS: Patients with acute liver failure (ALF) have defects in innate immune responses to microbes (immune paresis) and are susceptible to sepsis. Cytotoxic T-lymphocyte-associated protein 4 (CTLA4), which interacts with the membrane receptor
Ahmed El-Masry, Amy E. Anderson, Anand, Anderson, Anderson, Antoniades, Antoniades, Antoniades, Antoniades, Antoniades, Arjuna Singanayagam, Auzinger, Ayukawa, Barreto, Bernsmeier, Boomer, Brunner, Chang, Chang, Charalambos G. Antoniades, Christine Bernsmeier, Christopher J. Weston, Christopher Willars, Craig, Egen, Evangelos Triantafyllou, Fanny Lebosse, Fin S. Larsen, Flo, Gao, Georg Auzinger, Giovanna Lombardi, Grosso, Hotchkiss, Inoue, Jeannin, Julia Wendon, Krummel, Larsen, Leach, Liaskou, Liu, Lucia A. Possamai, Manjuck, Mark Thursz, Moreau, Nobuaki Kudo, Pedicord, Possamai, Riley, Robin D. Abeles, Roger, Roger, Rolando, Sakaguchi, Sansom, Scalapino, Schmidt, Schubert, Seder, Tie Zheng Hou, van der Merwe, Vaquero, Wafa Khamri, Walunas, William Bernal, Xiao, Zizzo, Zubairi   +68 more
core   +6 more sources

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Ceramide kinase-mediated C1P metabolism attenuates acute liver injury by inhibiting the interaction between KEAP1 and NRF2

Experimental and Molecular Medicine
Acute liver injury is the basis of the pathogenesis of diverse liver diseases. However, the mechanism underlying liver injury is complex and not completely understood. In our study, we revealed that CERK, which phosphorylates ceramide to produce ceramide-
Wei Dong, Qing Li, Xing Lu, Jianfeng Lan, Zhidong Qiu, Xuehong Wang, Junnan Wang, Xiaojiao Zheng, Sifan Chen, Chong Zhang, Junfei Jin   +10 more
doaj   +1 more source

LncRNA-Airn alleviates acute liver injury by inhibiting hepatocyte apoptosis via the NF-κB signaling pathway

Acta Biochimica et Biophysica Sinica, 2022
Acute liver injury is a common and serious syndrome caused by multiple factors and unclear pathogenesis. If the injury persists, liver injury can lead to cirrhosis and liver failure and ultimately results in the development of liver cancer.
Shao Shuai, Zhang Yu, Zhou Feng, Meng Xiaoxiang, Yu Zhenjun, Li Guantong, Zheng Lina, Zhang Kun, Li Yuhan, Guo Beichen, Liu Qi, Zhang Mengxia, Du Xiaoxiao, Hong Wei, Han Tao   +14 more
doaj   +1 more source

Bile Acid Receptor Therapeutics Effects on Chronic Liver Diseases [PDF]

, 2020
In the past ten years, our understanding of the importance of bile acids has expanded from fat absorption and glucose/lipid/energy homeostasis into potential therapeutic targets for amelioration of chronic cholestatic liver diseases.
Alpini, Gianfranco, Francis, Heather, Kennedy, Lindsey, Kundu, Debjyoti, Meadows, Vik   +4 more
core   +1 more source

Lamivudine-Induced Liver Injury

Open Access Macedonian Journal of Medical Sciences, 2015
BACKGROUND: Lamivudine is a nucleoside analogue antiretroviral drug, known for its low toxicity at clinically prescribed dose. However, the toxicity or mechanism of toxicity and target tissue effects during prolonged administration of higher doses were hardly given sufficient laboratory attention.AIM: The present work was designed to investigate the ...
Olaniyan, Lamidi W. B., Maduagwu, E. N., Akintunde, Olalekan Wasiu, Oluwayelu, Oladimeji O., Brai, Bartholomew I. C.   +4 more
openaire   +6 more sources

Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies

FEBS Open Bio, EarlyView.
Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa, Ilva Liekniņa, Svetlana Koteloviča, Ramona Petrovska, Gediminas Žvinys, Agne Petrosiute, Asta Zubrienė, Matīss Toms Laugalis, Vendija Skeltona, Juris Jansons, Madara Kreishmane, Edita Čapkauskaitė, Daumantas Matulis, Kaspars Tārs   +13 more
wiley   +1 more source