Results 131 to 140 of about 1,906,831 (271)

Probing the Role of CYP2 Enzymes in the Atropselective Metabolism of Polychlorinated Biphenyls Using Liver Microsomes from Transgenic Mouse Models. [PDF]

Chem Res Toxicol, 2022
Lehmler HJ, Uwimana E, Dean LE, Kovalchuk N, Zhang QY, Ding X.   +5 more
europepmc   +1 more source

First‐in‐Human Study of a Long‐Acting GLP‐1 Receptor Agonist (TE‐8105) in Overweight or Obese Adults Without Type 2 Diabetes Mellitus

The Journal of Clinical Pharmacology, Volume 66, Issue 8, August 2026.
Abstract Glucagon‐like peptide‐1 (GLP‐1) receptor agonists have revolutionized weight management and are becoming essential for the treatment of obesity‐related medical conditions. This study aimed to determine the pharmacokinetics, preliminary pharmacodynamics, safety, and tolerability of a long‐acting GLP‐1 receptor agonist, TE‐8105, in overweight or
Ya‐Shan Chuang, Jon D. Wright, Mun‐Teng Wong, Kushal J Paneliya, Wei‐Shiung Yang, Hsing‐Mao Chu, Tse Wen Chang, Thomas M Polasek   +7 more
wiley   +1 more source

Characterization of Atrasentan Metabolic Pathway in Human Liver Microsomes Using Feature-Based Molecular Networking. [PDF]

Pharmaceutics
Seo HJ, Liang Z, Kim EH, Liu KH.
europepmc   +1 more source

Assessment of In Silico and In Vitro Selpercatinib Metabolic Stability in Human Liver Microsomes Using a Validated LC-MS/MS Method. [PDF]

Molecules, 2023
Attwa MW, AlRabiah H, Mostafa GAE, Bakheit AH, Kadi AA.   +4 more
europepmc   +1 more source

Itching for a diagnosis: Dysesthesias as an atypical presentation of Wilson disease in an adolescent—Case report

JPGN Reports, Volume 7, Issue 3, Page 383-386, August 2026.
Abstract Wilson disease (WD) is an autosomal recessive disorder of hepatic copper metabolism with varied clinical presentations. We describe a 15‐year‐old male referred for elevated aminotransferases, burning facial pruritis, scalp dysesthesias, and chronic bilateral lower extremity edema.
Tierra L. R. Mosher, John Hicks, Krupa R. Mysore   +2 more
wiley   +1 more source

Reductive dominance and limited cytochrome P450 activity in neonicotinoid metabolism by elephant liver microsomes. [PDF]

J Vet Med Sci
Watanabe K, Khidkhan K, Saengtienchai A, Somgrid C, Towiboon P, Angkawanish T, Langkaphin W, Namwongprom K, Kittisirik N, Yohannes YB, Ikenaka Y, Nakayama SM, Ishizuka M.   +12 more
europepmc   +1 more source

Metabolite Identification of HIV-1 Capsid Modulators PF74 and 11L in Human Liver Microsomes. [PDF]

Metabolites, 2022
Xu S, Sun L, Ding D, Zhang X, Liu X, Zhan P.   +5 more
europepmc   +1 more source

Could NAPQI Contribute to Paracetamol Analgesia? Redox Modulation of Kv7 Ion Channels

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Paracetamol (acetaminophen, APAP) is one of the most widely used analgesic and antipyretic drugs worldwide, yet its mechanism of action remains incompletely understood. While several pathways have been proposed, including cyclooxygenase inhibition and endocannabinoid modulation via AM404, none fully account for its pharmacological profile. The
Sara M‐Alicante, Janire Urrutia, Arantza Muguruza‐Montero, Miren Revuelta, Ane Arrizabalaga‐Iriondo, Alvaro Villarroel, Eider Nuñez   +6 more
wiley   +1 more source

Toxicokinetic-Oriented Assessment of Nepetalactone Using In Silico ADMET Modeling, In Vitro Rat and Human Liver Microsomes, and UHPLC-MS/MS Metabolite Characterization. [PDF]

Toxics
Stoica NB, Cascajosa-Lira A, Morea A, Catunescu GM, Hornedo-Ortega R, Guzmán-Guillén R.   +5 more
europepmc   +1 more source

The Influence of Lipid Microdomain Heterogeneity on Protein-Protein Interactions: Proteomic Analysis of Co-Immunoprecipitated Binding Partners of P450 1A2 and P450 3A in Rat Liver Microsomes. [PDF]

Drug Metab Dispos, 2023
Reed JR, Guidry JJ, Eyer M, Backes WL.
europepmc   +1 more source