Results 121 to 130 of about 570,610 (302)

[Liver neoplasms in children].

Boletin medico del Hospital Infantil de Mexico, 1982
Presentation is made of 27 cases of liver neoplasms in infancy and childhood that were admitted to the Pediatric Hospital of the National Medical Center of the IMSS, through a period of 15 years. Sixteen cases were diagnosed as hepatoblastoma, 2 as hepatocellular carcinoma, 4 as mesenchymal hamartoma, 2 as hemangioendothelioma of infantile type, 2 were
H, Coronado Pérez, O, Angulo Hernández
openaire   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Diagnostic and therapeutic role of endoscopy in gastroenteropancreatic neuroendocrine neoplasms

, 2014
Gastroenteropancreatic neuroendocrine neoplasms have substantially increased over the last decades. Because of the indolent clinical course of the disease even in advance stages and the rise in the incidental diagnosis of small asymptomatic lesions, the ...
Attili F, Alberto Larghi, Larghi, Alberto, Fuccio, Lorenzo, Costamagna, Guido, DELLE FAVE, Gianfranco, Capurso G, Capurso, Gabriele, Vanella, Giuseppe, Lorenzo Fuccio, Fave, Gianfranco Delle, Fave GD, Larghi A., Attili, Fabia, Vanella G, Guido Costamagna, Costamagna G   +16 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Empirical distributions (o) of ED₀₁ study data on bladder neoplasms, liver neoplasms, and bladder carcinomas resulting from continuous exposure to the carcinogen 2-acetylaminofluoren, and fitted Weibull (—) and first-order time-transform (−) distributions.

, 2015
Columns 1–3: liver neoplasms, bladder neoplasms, and bladder carcinomas, respectively; Rows 1–3: 75, 100, and 150 ppm, respectively. Bladder neoplasm and bladder carcinoma data are identical at 75 and 100 ppm (all neoplasms malignant), therefore not ...
James D. Englehardt (752917)
core   +1 more source

Leiomioma hepático em paciente imunocompetente

Revista do Colégio Brasileiro de Cirurgiões
Diagnosis and treatment of hepatic tumors are a challenge for the surgeon in some situations. There are many histologic types of these neoplasms, and their diagnoses are increasing.
Antonio Nocchi Kalil, Marcelo Tonding Ferreira, Fernando Ressler, Cláudio Zettler   +3 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Burden of digestive system neoplasms in middle-aged and elderly adults: Temporal trends and geographic disparities (1990-2021).

PLoS ONE
ObjectiveThis study aims to comprehensively analyze the temporal trends and geographic disparities in the burden of seven digestive system neoplasms-esophageal cancer, stomach cancer, colon and rectum cancer, liver cancer, gallbladder and biliary tract ...
Yinying Chai, Tinghui Xu, Bihua Chen, Yi Wu, Yibo He, Shengliang Qiu   +5 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source