Quantitative Methods for Optimizing Patient Outcomes in Liver Transplantation [PDF]
Liver transplantation continues to be the gold standard for treating patients with end-stage liver diseases. However, despite the huge success of liver transplantation in improving patient outcomes, long term graft survival continues to be a major problem.
arxiv
Background. In the United States, 1 in 10 infants and 1 in 20 older children die on the liver transplant waiting list. Increasing split liver transplantation could increase organ availability for these children, without decreasing transplants in adults ...
E. Perito+4 more
semanticscholar +1 more source
A Method for Modeling Growth of Organs and Transplants Based on the General Growth Law: Application to the Liver in Dogs and Humans [PDF]
Understanding biological phenomena requires a systemic approach that incorporates different mechanisms acting on different spatial and temporal scales, since in organisms the workings of all components, such as organelles, cells, and organs interrelate.
arxiv +1 more source
Nonalcoholic fatty liver disease (NAFLD), a common cause of chronic liver disease (CLD), has a global prevalence of 25%. Its progressive form, nonalcoholic steatohepatitis (NASH), is a leading indication for liver transplantation (LT) in the United ...
Z. Younossi
semanticscholar +1 more source
Multi-Task Learning for Post-transplant Cause of Death Analysis: A Case Study on Liver Transplant [PDF]
Organ transplant is the essential treatment method for some end-stage diseases, such as liver failure. Analyzing the post-transplant cause of death (CoD) after organ transplant provides a powerful tool for clinical decision making, including personalized treatment and organ allocation. However, traditional methods like Model for End-stage Liver Disease
arxiv
Liver transplantation for hepatitis C virus (HCV) non‐viremic recipients with HCV viremic donors
In the context of organ shortage, the opioid epidemic, and effective direct‐acting antiviral (DAA) therapy for hepatitis C virus (HCV), more HCV‐infected donor organs may be used for liver transplantation.
A. Kwong+6 more
semanticscholar +1 more source
Method for finding metabolic properties based on the general growth law. Liver examples. A General framework for biological modeling [PDF]
We propose a method for finding metabolic parameters of cells, organs and whole organisms, which is based on the earlier discovered general growth law. Based on the obtained results and analysis of available biological models, we propose a general framework for modeling biological phenomena and discuss how it can be used in Virtual Liver Network ...
arxiv +1 more source
Physical frailty after liver transplantation
Frailty is prevalent in liver transplant candidates, but little is known of what happens to frailty after liver transplantation. We analyzed data for 214 adult liver transplant recipients who had ≥1 frailty assessment using the Liver Frailty Index (LFI ...
J. Lai+5 more
semanticscholar +1 more source
Explainable Machine Larning for liver transplantation [PDF]
In this work, we present a flexible method for explaining, in human readable terms, the predictions made by decision trees used as decision support in liver transplantation. The decision trees have been obtained through machine learning applied on a dataset collected at the liver transplantation unit at the Coru\~na University Hospital Center and are ...
arxiv
A Rule-Based System for Explainable Donor-Patient Matching in Liver Transplantation [PDF]
In this paper we present web-liver, a rule-based system for decision support in the medical domain, focusing on its application in a liver transplantation unit for implementing policies for donor-patient matching. The rule-based system is built on top of an interpreter for logic programs with partial functions, called lppf, that extends the paradigm of
arxiv +1 more source