Results 111 to 120 of about 7,990,457 (266)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

The ATP-binding cassette transporter 1 mediates lipid efflux from Sertoli cells and influences male fertility

Journal of Lipid Research, 2004
The liver X receptor/retinoid X receptor (LXR/RXR)-regulated gene ABCA1 effluxes cellular cholesterol and phospholipid to apolipoprotein A1 (apoA1), which is the rate-limiting step in high-density lipoprotein synthesis.
David M. Selva, Veronica Hirsch-Reinshagen, Braydon Burgess, Steven Zhou, Jeniffer Chan, Sean McIsaac, Michael R. Hayden, Geoffrey L. Hammond, A. Wayne Vogl, Cheryl L. Wellington   +9 more
doaj   +1 more source

Expressão, purificação e caracterização estrutural inicial do receptor órfão nuclear NOR-1 de rato [PDF]

, 2004
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em BiotecnologiaO receptor órfão nuclear NOR-1 é um membro uma superfamília composta por um grupo de fatores de transcrição ...
Maciel, Guilherme Razzera
core  

Activation of peroxisome proliferator-activated receptor alpha in human peripheral blood mononuclear cells reveals an individual gene expression profile response [PDF]

, 2007
Peripheral blood mononuclear cells (PBMCs) are relatively easily obtainable cells in humans. Gene expression profiles of PBMCs have been shown to reflect the pathological and physiological state of a person.
Afman, Lydia A., Bouwens, M., Müller, Michael, Müller Michael, Afman, Lydia, Afman, Lydia A, Afman, L.A., Michael Müller, Bouwens Mark, Müller, M.R., Mark Bouwens, Afman Lydia A, Bouwens, Mark, Lydia A Afman   +13 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Synergistic Steatosis Induction in Mice: Exploring the Interactions and Underlying Mechanisms between PFOA and Tributyltin

Cells
This study explores the impact of environmental pollutants on nuclear receptors (CAR, PXR, PPARα, PPARγ, FXR, and LXR) and their heterodimerization partner, the Retinoid X Receptor (RXR).
Yannick Dauwe, Lucile Mary, Fabiana Oliviero, Louise Dubois, Elodie Rousseau-Bacquie, Jelskey Gomez, Véronique Gayrard, Laïla Mselli-Lakhal   +7 more
doaj   +1 more source

Genetic association of liver X receptor beta rs2695121 polymorphism with obesity-related traits in a northeastern Iranian population

Electronic Physician, 2018
Background: Liver X receptor Beta (LXRβ), located in an obesity susceptible region, has been shown to be involved in the metabolism of lipid and carbohydrates.
Hassan Mehrad-Majd, Majid Ghayour-Mobarhan, Mohamad-Reza Zali   +2 more
doaj   +1 more source

Expression of parathyroid hormone-related protein in gastrointestinal malignancies. [PDF]

, 2006
Parathyroid hormone-related protein (PTHrP) is a peptide hormone which, when abundantly produced by certain tumours, and released into the systemic circulation, stimulates via an endocrine-like pathway, bone resorption and renal calcium reabsorption, by ...
McStay, M.K.G.
core  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Unlocking therapeutic potential: exploring cross-talk among emerging nuclear receptors to combat metabolic dysfunction in steatotic liver disease

npj Metabolic Health and Disease
Nuclear receptors (NRs) regulate cellular processes and serve as key targets in treating metabolic dysfunction-associated steatotic liver disease (MASLD) and steatohepatitis (MASH).
Milton Boaheng Antwi, Ariann Jennings, Sander Lefere, Dorien Clarisse, Anja Geerts, Lindsey Devisscher, Karolien De Bosscher   +6 more
doaj   +1 more source