Results 211 to 220 of about 792,189 (305)

Effects of liver X receptor in O3-induced airway inflammation and remodeling in mice. [PDF]

J Thorac Dis
Yu F, Ma J, Xu K, Tang Y, Wu B, Gu W, Shi Y.   +6 more
europepmc   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

SULF1/SULF2 reactivation during liver damage and tumour growth [PDF]

, 2016
A Giakoustidis, A Schulze, AP Sahota, C Bret, CL Merry, D Shukla, DC Kroy, G Xu, G Zaman, GK Dhoot, GK Dhoot, Gurtej K. Dhoot, H Barth, H Lemjabbar-Alaoui, J Lai, Joshua I. Murphy, JP Lai, JP Lai, JP Lai, JWY Tuo, K Uchimura, Kurtis Graham, L Hitchins, M Ford-Perriss, M Meyers-Needham, M Morimoto-Tomita, M Tarocchi, MT Joy, P Tátrai, R Gill, R Nawroth, RB Gill, RB Gill, RM Gill, S Ashikari-Hada, S Wang, S Wang, SD Rosen, X Ai, X Ai, Y Xu, YC Kwon   +41 more
core   +1 more source

Physiological activation of liver X receptor provides protection against ocular inflammation in uveitic glaucoma. [PDF]

Biochim Biophys Acta Mol Basis Dis
Ju HH, Lee J, Kim SK, Kim SY, Ahn JH, Skiba NP, Rao PV, Choi JA.   +7 more
europepmc   +1 more source

Liver X receptor agonists exert antitumor effects against hepatocellular carcinoma via inducing REPS2 expression. [PDF]

Acta Pharmacol Sin, 2023
He XY, Zhu MM, Zheng J, Wang CY, Zhao XK, Zhang BT, Zhou DC, Zhang S, Yang XX, Duan YJ, Han JH, Chen YL.   +11 more
europepmc   +1 more source

Ultrasmall Platinum Nanoparticles for Radiation‐Enhanced Cancer Therapy

Advanced Functional Materials, EarlyView.
This work proposes a nanomedicine‐based strategy to enhance X‐ray radiotherapy for cancer treatment. Ultrasmall Pt‐NPs exhibit catalase‐like activity that may contribute to modulation of the tumor microenvironment and amplify interactions between radiation and biological matter, leading to increased DNA damage.
Miguel Encinas‐Gimenez, Jose I. Garcia‐Peiro, Jose L. Hueso, Eduardo Caleiras, Laura Notario, Felipe Hornos, Pilar Martin‐Duque, Antonio De la Vieja, Jesus Santamaria   +8 more
wiley   +1 more source

Damaging mutations in liver X receptor-α are hepatotoxic and implicate cholesterol sensing in liver health. [PDF]

Nat Metab
Lockhart SM, Muso M, Zvetkova I, Lam BYH, Ferrari A, Schoenmakers E, Duckett K, Leslie J, Collins A, Romartínez-Alonso B, Tadross JA, Jia R, Gardner EJ, Kentistou K, Zhao Y, Day F, Mörseburg A, Rainbow K, Rimmington D, Mastantuoni M, Harrison J, Nus M, Guma'a K, Sherratt-Mayhew S, Jiang X, Smith KR, Paul DS, Jenkins B, Koulman A, Pietzner M, Langenberg C, Wareham N, Yeo GS, Chatterjee K, Schwabe J, Oakley F, Mann DA, Tontonoz P, Coll AP, Ong K, Perry JRB, O'Rahilly S.   +41 more
europepmc   +1 more source

Liver X Receptor Agonist Inhibits Oxidized Low-Density Lipoprotein Induced Choroidal Neovascularization via the NF-κB Signaling Pathway. [PDF]

J Clin Med, 2023
Wu T, Wei X, Dang K, Tao M, Lv B, Chen T, Zhang Z, Zhou J, Du H.   +8 more
europepmc   +1 more source

Multiplex Modular Nanorobotic Systems with Catalytic Activity under Magnetic Navigation

Advanced Functional Materials, EarlyView.
We present modular nanorobots composed of a magnetic propulsion module and different extension modules carrying functional activities, assembled via DNA base pairing. The system integrates propulsion, optical tracking, enzymatic catalysis, and cell docking in a programmable manner.
Voichita Mihali, Xinan Huang, Lucie Motyckova, Nicolas Moreno Gomez, Michal Skowicki, Cora‐Ann Schoenenberger, Peer Fischer, Cornelia G. Palivan   +7 more
wiley   +1 more source

Investigation of Liver X Receptor Gene Variants and Oxysterol Dysregulation in Autism Spectrum Disorder. [PDF]

Children (Basel)
Menteşe Babayiğit T, Gümüş-Akay G, Uytun MÇ, Doğan Ö, Serdar MA, Efendi GY, Erman AG, Yürümez E, Öztop DB.   +8 more
europepmc   +1 more source