Results 261 to 270 of about 792,189 (305)

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury

Advanced Healthcare Materials, EarlyView.
This study demonstrates that ALY688, a drug mimicking the heart‐protective hormone adiponectin, reduces myocardial ischemia injury. ALY688 increases the production of extracellular vesicles, which carry protective cargo including adiponectin itself.
Jialing Tang, Wing Yan Chung, Serena M. Pulente, Yubin Lei, Khang Nguyen, Eddie Tam, Nadya M. Morrow, Ilka Lorenzen‐Schmidt, Fengxia Xiao, Augusto Zani, Dylan Burger, Hye Kyoung Sung, Erin E. Mulvihill, Gary Sweeney   +13 more
wiley   +1 more source

Correction: Enhanced expression of pro-inflammatory mediators and liver X-receptor-regulated lipogenic genes in non-alcoholic fatty liver disease and hepatitis C. [PDF]

Clin Sci (Lond)
europepmc   +1 more source

Biological role of liver X receptors

Journal of Physiology and Pharmacology, 2008
openaire  

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Liver X receptors and liver physiology

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2021
The liver x receptors LXRα (NR1H3) and LXRβ (NR1H2) are members of the nuclear hormone receptor superfamily of ligand dependent transcription factors that regulate transcription in response to the direct binding of cholesterol derivatives. Studies using genetic knockouts and synthetic ligands have defined the LXRs as important modulators of lipid ...
Lillian, Russo-Savage, Ira G, Schulman
openaire   +2 more sources

Targeting liver X receptors in inflammation

Expert Opinion on Therapeutic Targets, 2013
The two oxysterol receptors, 'liver X receptors (LXRs)' LXRα and LXRβ, are amongst the emerging newer drug targets within the nuclear receptor family and targeting LXRs represents novel strategies needed for prevention and treatment of diseases where current therapeutics is inadequate.This review discusses the current understanding of LXR biology with ...
Knut R, Steffensen, Tomas, Jakobsson, Jan-Åke, Gustafsson   +2 more
openaire   +2 more sources

A structural perspective of liver X receptors

2023
Liver X receptors α and β are members of the nuclear receptor family, which comprise a flexible N-terminal domain, a DNA binding domain, a hinge linker, and a ligand binding domain. Liver X receptors are important regulators of cholesterol and lipid homeostasis by controlling the transcription of numerous genes.
Jan-Åke, Gustafsson, Xian Chang, Li, Ji Ho, Suh, Xiaohua, Lou   +3 more
openaire   +2 more sources

Pregnane X Receptor Activation in Liver Perfusion

Transplantation Proceedings, 2022
Liver normothermic machine perfusion (NMP) is being adopted as a method of optimizing livers before transplantation. However, there is further potential to use the NMP model as a platform for drug delivery. Pregnane X receptor (PXR) activation upregulates CYP3A expression and has been shown to be protective against ischemia-reperfusion in rodents.
Samuel Moulding, Rodrigo Figueiredo, Avinash Sewpaul, Alistair Leitch, Lucy Bates, Matthew Wright, Colin Wilson   +6 more
openaire   +3 more sources

Action mechanisms of Liver X Receptors

Biochemical and Biophysical Research Communications, 2014
The two Liver X Receptors, LXRα and LXRβ, are nuclear receptors belonging to the superfamily of ligand-activated transcription factors. They share more than 78% homology in amino acid sequence, a common profile of oxysterol ligands and the same heterodimerization partner, Retinoid X Receptor. LXRs play crucial roles in several metabolic pathways: lipid
Chiara, Gabbi, Margaret, Warner, Jan-Åke, Gustafsson   +2 more
openaire   +2 more sources

Enolase is regulated by Liver X Receptors

Steroids, 2015
Enolase is a glycolytic enzyme known to inhibit cholesteryl ester hydrolases (CEHs). Cholesteryl ester loading of macrophages, as occurs during atherosclerosis, is accompanied by increased Enolase protein and activity. Here, we describe that J774 macrophages treated with LXR agonists exhibit reduced Enolase transcript and protein abundance.
de Boussac, Hugues, Maqdasy, Salwan, Trousson, Amalia, Zelcer, Noam, Volle, H., Lobaccaro, A., Baron, Silvere   +6 more
openaire   +3 more sources