Results 151 to 160 of about 520,167 (196)

Macrophage-independent regulation of reverse cholesterol transport by liver X receptors. [PDF]

Arterioscler Thromb Vasc Biol, 2014
Breevoort SR, Angdisen J, Schulman IG.
europepmc   +1 more source

Liver X receptors contribute to periodontal pathogen-elicited inflammation and oral bone loss. [PDF]

Mol Oral Microbiol, 2015
Huang N, Shaik-Dasthagirisaheb YB, LaValley MP, Gibson FC.   +3 more
europepmc   +1 more source

Liver X receptors alpha and beta promote myelination and remyelination in the cerebellum. [PDF]

Proc Natl Acad Sci U S A, 2015
Meffre D, Shackleford G, Hichor M, Gorgievski V, Tzavara ET, Trousson A, Ghoumari AM, Deboux C, Nait Oumesmar B, Liere P, Schumacher M, Baulieu EE, Charbonnier F, Grenier J, Massaad C.   +14 more
europepmc   +1 more source

Liver X receptors constrain tumor development and metastasis dissemination in PTEN-deficient prostate cancer.

Nat Commun, 2017
Alioui A, Dufour J, Leoni V, Loregger A, Moeton M, Iuliano L, Zerbinati C, Septier A, Val P, Fouache A, Russo V, Volle DH, Lobaccaro JA, Zelcer N, Baron S.   +14 more
europepmc   +1 more source

Statement of Retraction: Liver X Receptors Activation Attenuates Ischemia Reperfusion Injury of Liver Graft in Rats

Journal of Investigative Surgery
doaj   +1 more source

Biological role of liver X receptors

Journal of Physiology and Pharmacology, 2008
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Pregnane X Receptor Activation in Liver Perfusion

Transplantation Proceedings, 2022
Liver normothermic machine perfusion (NMP) is being adopted as a method of optimizing livers before transplantation. However, there is further potential to use the NMP model as a platform for drug delivery. Pregnane X receptor (PXR) activation upregulates CYP3A expression and has been shown to be protective against ischemia-reperfusion in rodents.
Samuel Moulding, Rodrigo Figueiredo, Avinash Sewpaul, Alistair Leitch, Lucy Bates, Matthew Wright, Colin Wilson   +6 more
openaire   +3 more sources

Action mechanisms of Liver X Receptors

Biochemical and Biophysical Research Communications, 2014
The two Liver X Receptors, LXRα and LXRβ, are nuclear receptors belonging to the superfamily of ligand-activated transcription factors. They share more than 78% homology in amino acid sequence, a common profile of oxysterol ligands and the same heterodimerization partner, Retinoid X Receptor. LXRs play crucial roles in several metabolic pathways: lipid
Chiara, Gabbi, Margaret, Warner, Jan-Åke, Gustafsson   +2 more
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Targeting liver X receptors in inflammation

Expert Opinion on Therapeutic Targets, 2013
The two oxysterol receptors, 'liver X receptors (LXRs)' LXRα and LXRβ, are amongst the emerging newer drug targets within the nuclear receptor family and targeting LXRs represents novel strategies needed for prevention and treatment of diseases where current therapeutics is inadequate.This review discusses the current understanding of LXR biology with ...
Knut R, Steffensen, Tomas, Jakobsson, Jan-Åke, Gustafsson   +2 more
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Liver X Receptors, Atherosclerosis and Inflammation

Current Atherosclerosis Reports, 2012
Liver X receptors (LXRs) belong to the nuclear receptor superfamily of ligand-dependent transcription factors. LXRs are activated by oxysterols, metabolites of cholesterol, and therefore act as intracellular sensors of this lipid. There are two LXR genes (α and β) that display distinct tissue/cell expression profiles.
Daryn R, Michael, Tim G, Ashlin, Melanie L, Buckley, Dipak P, Ramji   +3 more
openaire   +2 more sources