Results 51 to 60 of about 520,167 (196)
Journal of Pharmacological Sciences, 2005 Nuclear receptors are ligand-dependent transcription factors that recently have been shown to play important roles in the metabolism of cholesterol and bile acids.
Makoto Makishima
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LXR agonist improves peripheral neuropathy and modifies PNS immune cells in aged mice
Journal of Neuroinflammation, 2022 Background Peripheral neuropathy is a common and progressive disorder in the elderly that interferes with daily activities. It is of importance to find efficient treatments to treat or delay this age-related neurodegeneration.
Chaitanya K. Gavini +5 more
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The liver X receptor pathway is highly upregulated in rheumatoid arthritis synovial macrophages and potentiates TLR-driven cytokine release [PDF]
, 2013 <p>Objectives: Macrophages are central to the inflammatory processes driving rheumatoid arthritis (RA) synovitis. The molecular pathways that are induced in synovial macrophages and thereby promote RA disease pathology remain poorly understood.</
Ananth +42 more
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Bile acids as global regulators of hepatic nutrient metabolism
Liver Research, 2017 Bile acids (BA) are synthesized from cholesterol in the liver. They are essential for promotion of the absorption of lipids, cholesterol, and lipid-soluble vitamins from the intestines.
Phillip B. Hylemon +4 more
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Thyroxine-binding globulin: investigation of microheterogeneity [PDF]
, 1981 Preparations of T4-binding globulin (TBG) from human serum was performed using only two affinity chromatography steps. Purity of the protein was demonstrated by a single band in overloaded disc and sodium dodecyl sulfate electrophoresis, equimolar ...
Gärtner, Roland +4 more
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Liver X Receptor Signaling Pathways and Atherosclerosis [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2010 First discovered as orphan receptors, liver X receptors (LXRs) were subsequently identified as the nuclear receptor target of the cholesterol metabolites, oxysterols. There are 2 LXR receptors encoded by distinct genes: LXRα is most highly expressed in the liver, adipose, kidney, adrenal tissues, and macrophages and LXRβ is ubiquitously expressed ...
Anna C, Calkin, Peter, Tontonoz
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Liver X Receptor: A novel therapeutic target
Indian Journal of Pharmaceutical Sciences, 2008 The liver X receptors alpha and beta are orphan nuclear receptors that are key regulators in maintaining cholesterol homeostasis. Originally they were found to play an important role in reverse cholesterol transport, a pathway for the removal of excess cellular cholesterol. However several groups have now shown that the liver X receptors also functions
Patel, M. B. +4 more
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Liver X receptors and fat cell metabolism [PDF]
International Journal of Obesity, 2012 Liver X receptors (LXRs) are members of the nuclear receptor family and are present in two isoforms, α and β, encoded by two separate genes. Originally described in the liver, LXRs have in the last 15 years been implicated in central metabolic pathways, including bile acid synthesis, lipid and glucose homeostasis.
Laurencikiene, J, Rydén, M
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Liver x receptors protect from development of prostatic intra-epithelial neoplasia in mice. [PDF]
PLoS Genetics, 2013 LXR (Liver X Receptors) act as "sensor" proteins that regulate cholesterol uptake, storage, and efflux. LXR signaling is known to influence proliferation of different cell types including human prostatic carcinoma (PCa) cell lines.
Aurélien J C Pommier +11 more
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Corepressor diversification by alternative mRNA splicing is species specific. [PDF]
, 2016 BackgroundSMRT and NCoR are corepressor paralogs that help mediate transcriptional repression by a variety of transcription factors, including the nuclear hormone receptors.
Goodson, Michael L +2 more
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