Results 211 to 220 of about 4,166,240 (311)

Physical activity and dose-characteristics in free-living conditions among patients awaiting coronary artery bypass graft surgery: a cross-sectional study. [PDF]

BMC Cardiovasc Disord
Dijkstra S, Tasbihgou SR, Tigchelaar I, Atmosoerodjo SD, Huet R, van der Woude LHV, Mariani MA, Absalom AR.   +7 more
europepmc   +1 more source

Wearable derived cardiovascular responses to stressors in free-living conditions. [PDF]

PLoS One, 2023
Presby DM, Jasinski SR, Capodilupo ER.
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

The need for community-controlled tools to monitor health impacts of housing and living conditions in Australia. [PDF]

Front Public Health
Wyber R, Summer K, Stacey I, Stiles S, Katzenellenbogen J, Bowen AC, Burgess R.   +6 more
europepmc   +1 more source

Living with dementia and other long-term conditions: what works for patient-caregiver dyads? A realist review

Melanie Handley, Greg Windle, Elspeth Mathie, Honey-Anne Greco, Benjamin R. Underwood, Claire Surr, Karen Harrison Dening, Steve Milton, Amit Pujari, Reda Lebcir, Jennifer Lynch, Lucy Beishon, Elizabeth L Sampson, Reinhold Scherer, Claire Goodman   +14 more
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Living Conditions and Public Health Challenges in Temporary Camps for Displaced Populations in Shendi Locality, Sudan. [PDF]

J Epidemiol Glob Health
Ali ASMA, Khamees RAA.
europepmc   +1 more source

WASTE PRODUCTS OF HEAT POWER INDUSTRY AS A POWERFUL FACTOR AFFECTING PUBLIC HEALTH AND LIVING CONDITIONS OF POPULATION

, 2020
Valeryi Stankevich, Аlla Kostenko, Grygoryi Trakhtengerz   +2 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Substituting sitting with standing and walking in free-living conditions improves daily glucose concentrations in South Asian adults living with overweight/obesity. [PDF]

Eur J Appl Physiol
Dey KC, Zakrzewski-Fruer JK, Smith LR, Jones RL, Maylor BD, Yates TE, Bailey DP.   +6 more
europepmc   +1 more source