Results 51 to 60 of about 142,808 (310)

Behaviour of non-donor specific antibodies during rapid re-synthesis of donor specific HLA antibodies after antibody incompatible renal transplantation [PDF]

, 2013
Background: HLA directed antibodies play an important role in acute and chronic allograft rejection. During viral infection of a patient with HLA antibodies, the HLA antibody levels may rise even though there is no new immunization with antigen ...
Rizwan Hamer, Imray, C. (Chris), Nithya S Krishnan, Lam Chin Tan, Higgins Robert M., Daga Sunil, Lowe, David Philip, David Briggs, Zehnder Daniel, Tan Lam Chin, Zehnder, Daniel, Robert M Higgins, Daniel Zehnder, Kashi Habib, Dave Lowe, Christopher Imray, Sunil Daga, Neil Raymond, Krishnan, Nithya S., Lam, F. T., Higgins, Rob, Lam F. T., Habib Kashi, Daga, Sunil, F T Lam, Krishnan Nithya S., Lowe Dave, Hamer, Rizwan, Briggs David, Kashi, Habib, Briggs, David, Dr., Raymond Neil, Raymond, Neil T., Hamer Rizwan, Tan, Lam Chin, Imray Christopher   +35 more
core   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

miR-455/GREM1 axis promotes colorectal cancer progression and liver metastasis by affecting PI3K/AKT pathway and inducing M2 macrophage polarization

Cancer Cell International
Background Colorectal cancer is among the most common malignant tumors affecting the gastrointestinal tract. Liver metastases, a complication present in approximately 50% of colorectal cancer patients, are a considerable concern.
Shipeng Dai, Fan Xu, Xiaozhang Xu, Tian Huang, Yiming Wang, Hongyu Wang, Yucheng Xie, Lei Yue, Wenhu Zhao, Yongxiang Xia, Jian Gu, Xiaofeng Qian   +11 more
doaj   +1 more source

Midazolam exhibits antitumour and enhances the efficiency of Anti-PD-1 immunotherapy in hepatocellular carcinoma

Cancer Cell International, 2022
Background Midazolam (MDZ) is an anaesthetic that is widely used for anxiolysis and sedation. More recently, MDZ has also been described to be related to the outcome of various types of carcinomas.
Junwei Kang, Zhiying Zheng, Xian Li, Tian Huang, Dawei Rong, Xinyang Liu, Miaomiao Qin, Yuliang Wang, Xiangyi Kong, Jinhua Song, Chengyu Lv, Xiongxiong Pan   +11 more
doaj   +1 more source

Increased Risk of Sarcomas in Children With Congenital Anomalies: Findings From the Genetic Overlap Between Anomalies and Cancer in Kids (GOBACK) Registry Linkage Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric sarcomas are a heterogeneous group of tumors that contribute disproportionately to cancer mortality in children. Although congenital anomalies are among the strongest known risk factors for childhood cancer, the risk of specific sarcoma subtypes among affected individuals has not yet been thoroughly evaluated. Procedure We
Russ Wolters, Ji Yun Tark, Tiffany M. Chambers, Tania A. Desrosiers, Michael E. Scheurer, Charles Shumate, Wendy N. Nembhard, Mahsa M. Yazdy, Eirini Nestoridi, Amanda E. Janitz, Jean Paul Tanner, Russell S. Kirby, Jason L. Salemi, Yao Yu, Chad D. Huff, Sharon E. Plon, Philip J. Lupo, Jeremy M. Schraw   +17 more
wiley   +1 more source

ESRP1-mediated biogenesis of circPTPN12 inhibits hepatocellular carcinoma progression by PDLIM2/ NF-κB pathway

Molecular Cancer
Background Emerging evidence indicates the pivotal involvement of circular RNAs (circRNAs) in cancer initiation and progression. Understanding the functions and underlying mechanisms of circRNAs in tumor development holds promise for uncovering novel ...
Yang Ji, Chuangye Ni, Yanjun Shen, Zhenggang Xu, Lei Tang, Fei Yu, Lingbang Zhu, Hao Lu, Chuanyong Zhang, Shikun Yang, Xuehao Wang   +10 more
doaj   +1 more source

miR-139-5p sponged by LncRNA NEAT1 regulates liver fibrosis via targeting β-catenin/SOX9/TGF-β1 pathway

Cell Death Discovery, 2021
Liver fibrosis is a patho-physiological process which can develop into cirrhosis, and hepatic carcinoma without intervention. Our study extensively investigated the mechanisms of lncRNA NEAT1 and miR-139-5p in regulating liver fibrosis progression.
Qi Wang, Song Wei, Lei Li, Qingfa Bu, Haoming Zhou, Wantong Su, Zheng Liu, Mingming Wang, Ling Lu   +8 more
doaj   +1 more source

A New Porcine Model of Autologous Living-donor Liver Transplantation [PDF]

, 2008
Background: Living-donor liver transplantation（ LDLT） requires greater surgical experience, higher technical skills, and a more complete understanding of the hepatobiliary system than whole-liver transplantation from brain-dead donors.
Sakuma, Yasunaru, Yasuda, Toshihiko, Yasuda, Yoshikazu, Hojo, Nobuyuki, Ishibashi, Toshimitsu, Fujiwara, Taketo, Nagai, Hideo   +6 more
core  

Considering adult living donor liver transplantation: a qualitative study of patients and their potential donors [PDF]

, 2010
In April 2006, the Scottish Liver Transplant Unit became the first NHS transplant unit in the UK to offer adult Living Donor Liver Transplantation (LDLT). However, within the first 21 months of its availability, no patients on the transplant waiting list
McGregor, Lesley M, Hayes, Peter C, Forsythe, John R, Swanson, Vivien, O'Carroll, Ronan   +4 more
core   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source