Results 41 to 50 of about 858,253 (312)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Dermatophagoides farinae microRNAs released to external environments via exosomes regulate inflammation-related gene expression in human bronchial epithelial cells

Frontiers in Immunology, 2023
BackgroundDermatophagoides farinae (DFA) is an important species of house dust mites (HDMs) that causes allergic diseases. Previous studies have focused on allergens with protein components to explain the allergic effect of HDMs; however, there is little
Kaiyue He, Ting Yang, Jinyan Yu, Xiao Zang, Shangde Jiang, Shuyue Xu, Jiaxi Liu, Zuyu Xu, Wei Wang, Shanchao Hong   +9 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Considering people living with dementia when designing interfaces [PDF]

, 2014
Dementia is an escalating problem which is estimated to affect 35.6 million people worldwide. In an environment which is becoming increasingly dependent on technology, the interaction needs of people living with dementia is being ignored by interface ...
Good, Alice, Ancient, Claire, Alice Good, Claire Ancient   +3 more
core   +1 more source

Associations Between Eye-Level Streetscape Elements Along the Shortest Route to Parks and Residents’ Daily Walking: Empirical Evidence from Community-Led Walking Promotion Projects

Transportation Research Interdisciplinary Perspectives
Walking is a common form of physical activity that contributes to better health, and parks are important spatial settings for walking. Street conditions play an important role in park accessibility.
Xiaorui Wang, Erika Matsumoto, Daisuke Matsushita   +2 more
doaj   +1 more source

Urban planning regulation of the suburban zone of Ekaterinburg

Архитектон, 2023
The article outlines the prerequisites for and the concept of modern urban planning regulation of suburban zones around large cities withinin agglomeration settlement systems, where "smart" management of area development is needed on the basis of an ...
Kolyasnikov Victor A., Nadymov Ivan I.
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Illness related uncertainty in the lives of people living with HIV [PDF]

, 2020
Section A This systematic literature review analysed twenty-three qualitative and quantitative studies investigating the experiences of illness uncertainty in the lives of people living with HIV.
Zito, R.
core  

Ti3C2 mediates the NiFe-LDH layered electrocatalyst to enhance the OER performance for water splitting

Heliyon
Oxygen evolution reaction (OER) is a very complex process with slow reaction kinetics and high overpotential, which is the main limitation for the commercial application of water splitting.
Yaxun Sun, Ze Wang, Qianyu Zhou, Xin Li, Dongye Zhao, Bo Ding, Shifeng Wang   +6 more
doaj   +1 more source