Results 51 to 60 of about 710,352 (263)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Usability Analysis of Smart Speakers from a Learnability Perspective for Novel Users

Applied System Innovation
Although commercial smart speakers are becoming increasingly popular, there is still much potential for investigation into their usability. In this study, we analyzed the usability of commercial smart speakers by focusing on the learnability of young ...
Toshihisa Doi, Yuki Nishikawa
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Improving locomotive syndrome risk level through community‐led activities to establish walking habits

Japan Architectural Review
We evaluated the effects of walking habits and mobility improvement on an aging population among 30 residents of a suburban residential complex with the aim of promoting sustainable health activities led by residents.
Daisuke Matsushita, Yangcheng Gu
doaj   +1 more source

Assessing the risk of extreme precipitation in Japan through GEV distribution and spatial modeling

Journal of Hydrology: Regional Studies
Study region: Japan, characterized by diverse climatic zones and complex topography, has experienced increasing frequency and severity of extreme precipitation events in recent decades.
Zhichao Jiao, Jihui Yuan, Craig Farnham, Kazuo Emura   +3 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Shading effects on building energy performance: A multi-city analysis

Results in Engineering
This study presents a simplified methodology to evaluate the effects of surrounding shading elements—such as nearby buildings and trees—on building thermal loads, with a focus on passive cooling.
Xiong Xiao, Jihui Yuan, Zhichao Jiao, Shaoyu Sheng, Jiale Chai, Xiangfei Kong, Craig Farnham, Kazuo Emura   +7 more
doaj   +1 more source

Climate-driven shifts in sediment chemistry enhance methane production in northern lakes

Nature Communications, 2018
Methane emissions from lakes vary by orders of magnitude, leaving large uncertainty in regional and global carbon budgets. Here the authors show that phenols from forest litter act as a latch to suppress microbial activity and produce over 400-times less
E. J. S. Emilson, M. A. Carson, K. M. Yakimovich, H. Osterholz, T. Dittmar, J. M. Gunn, N. C. S. Mykytczuk, N. Basiliko, A. J. Tanentzap   +8 more
doaj   +1 more source