Results 61 to 70 of about 858,253 (312)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

An Analysis Method of Anticipated UX Evoked by Packaging Design Using the Evaluation Grid Method: A Case of the Analysis of Packages of Boxed Flour Confections and Sunscreen

Applied Sciences
When considering the chronological order of product use, package design is mainly related to forming the anticipated UX, which predicts and imagines the experience gained from interacting with the product.
Toshihisa Doi, Aoi Nagata
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Usability Analysis of Smart Speakers from a Learnability Perspective for Novel Users

Applied System Innovation
Although commercial smart speakers are becoming increasingly popular, there is still much potential for investigation into their usability. In this study, we analyzed the usability of commercial smart speakers by focusing on the learnability of young ...
Toshihisa Doi, Yuki Nishikawa
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Network of Extended Reality-Enabled Laboratories for Remote Practical Training: Didactic in Between Virtual and Real Living Environment

The integration of extended reality (XR) technologies in remote practical training offers immersive learning experiences through virtual simulations.
Lamonaca, Francesco, Carnì, Domenico Luca, Bilotta, Eleonora, Spadafora, Giuseppe, Palermo, Anna Maria, Liccardo, Annalisa   +5 more
core   +1 more source

A theoretical review in evaluating the impact of traffic calming measures on the residential living environment [PDF]

, 2012
A healthy living environment is vital to the positive lifestyle of a community. When traffic volumes or vehicle speeds in residential areas increase because of street design, social street activities are greatly reduced, and the feeling of well being in ...
Kadar Hamsa, Abdul Azeez, Rosli, Nur Shazwani   +1 more
core  

Environment, living spaces, and health: compound-organisation practices in a Bamako squatter settlement, Mali

, 2001
This article is based on a study conducted in Samé, a squatter settlement on the outskirts of Bamako, capital of Mali. The objective was to observe how individuals and their families ensure health and well-being through organising everyday life in their ...
Simard, Paule, De Koninck, Maria
core   +1 more source