Results 81 to 90 of about 8,459,231 (297)

Climate-driven shifts in sediment chemistry enhance methane production in northern lakes

Nature Communications, 2018
Methane emissions from lakes vary by orders of magnitude, leaving large uncertainty in regional and global carbon budgets. Here the authors show that phenols from forest litter act as a latch to suppress microbial activity and produce over 400-times less
E. J. S. Emilson, M. A. Carson, K. M. Yakimovich, H. Osterholz, T. Dittmar, J. M. Gunn, N. C. S. Mykytczuk, N. Basiliko, A. J. Tanentzap   +8 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

How do nature-based interventions increase the resilience of older persons? A best fit framework synthesis

BMC Geriatrics
Background Nature-based interventions (NBIs) are currently gaining popularity as a non-medical approach in health promotion. Resilience is a logical target for this type of interventions aimed at older adults.
Tom Cornu, Bruno Marchal, Hans Keune, Roy Remmen, Ben Delbaere, Joris Michielsen   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Influence of environment on residence and selected demographic and clinical parameters of preschool children with IgE-dependent asthma

Annals of Agricultural and Environmental Medicine, 2019
Introduction and objective An important role in the pathogenesis of asthma in children is played by individual parameters and environmental factors, in particular, those related to the place of residence. The aim of this study was to assess the impact of
Anna Bednarek, Robert Klepacz, Anna Surtel, Anna Mazur, Tomasz Saran, Danuta Zarzycka, Andrzej Emeryk   +6 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Synergistic adsorption and photocatalysis study of TiO2 and activated carbon composite

Heliyon
The discharge of organic pollutants by the textile and dyeing industries presents an escalating threat to aquatic environments, necessitating the development of effective remediation strategies.
Yihang Yue, Xiaoju Yue, Xiaofeng Tang, Lin Han, Jinnong Wang, Shifeng Wang, Chun Du   +6 more
doaj   +1 more source