Results 111 to 120 of about 3,379,585 (304)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Museum Theatre in Greece: Perspectives in Site Interpretation

open access: yesEXARC Journal, 2015
The paper summarizes preliminary findings of a research project on the use of museum theatre in Greek open-air sites, as a part of a PhD thesis. The research focuses on the exploration of the development, use and function of museum theatre in Greek open ...
Foteini Venieri, Niki Nikonanou
doaj  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

The Value of Experience: Lessons from a Study of Reenactment

open access: yesEXARC Journal, 2016
It is no secret that in many ways experimental archaeology overlaps with what has come to be called experiential archaeology, an interpretive and humanistic approach to the past.
Samantha Hartford
doaj  

Uneven and combined development: modernity, modernism, revolution [PDF]

open access: yes, 2017
Trotsky’s theory of Uneven and Combined Development was born out of his experience of the Russian Revolution. To mark the centenary of the revolution, we are publishing a series of five pieces by Neil Davidson that explore the theory’s wider contribution
Davidson, Neil
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The VIA SCIPIONIS Project Outdoor Travelling Experimental Archaeology and Re-enactment

open access: yesEXARC Journal, 2016
In August 2015 the first rendition of an experimental archaeology project was held, for the first time in Spain. The objective was to study the problems faced by the Roman Republican legions from the second Punic War during their marches.
José Miguel Gallego Cañamero   +3 more
doaj  

Glyptostrobus europaeus (Brongn.) Heer in Arkansas [PDF]

open access: yes, 1970
Glyptostrobus europaeus (Brongn.) Heer, a fossil gymnosperm is found at a few locations in central North America, in deposits of the Eocene. This work cites previously reported localities and reports a new site at Hooker, Arkansas.
Wittlake, Eugene B.
core   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Living History Fiction

open access: yesPapers: Explorations into Children's Literature, 2010
During my research into historical fiction for children and young adult readers I came across a range of texts that relied on a living or lived experience of history to frame the historical story. These novels were similar to the time-slip narrative; however, not all examples used the traditional convention of time-slippage.
openaire   +2 more sources

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