Results 121 to 130 of about 913,122 (305)

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Connecting with citizen journalists: an exploratory Living lab study on motivations for using mobile reporting applications [PDF]

, 2014
In the context of user generated content in the newsroom, mobile reporting applications are seen as a facilitator of citizen journalism, bringing news items from the user to the newsroom and vice versa.
Baccarne, Bastiaan, Schuurman, Dimitri, Vandenbroucke, Karel   +2 more
core  

Guidelines Towards Better Participation of Older Adults in Software Development Processes using a new SPIRAL Method and Participatory Approach

, 2018
This paper presents a new method of engaging older participants in the process of application and IT solutions development for older adults for emerging IT and tech startups.
Aula Anne, Knapp Jake, Naumanen Minnamari, Orzeszek D., Sanders Elizabeth B-N, Schumacher Jens   +5 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Living Lab in Computer Information Technology [PDF]

, 2011
poster abstractResearch Subject is the Living Lab in CIT, an experiential learning environment where students gain real IT experience.The Living Lab allows students to apply networking, security, database, website, and application development concepts ...
Justice, Connie
core  

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Marco metodológico para la implementación y evaluación de Living Labs [PDF]

, 2008
El Living Lab constituye un enfoque de investigación para la innovación que desafía todo el proceso de innovación e investigación en condiciones de la vida real mediante aspectos institucional, organizacional, cultural, social y humano, teniendo un ...
García Guzmán, Javier
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

A Review of Urban Living Labs Experiences with Emphasis on the Implementation of Environment-Based Smart Cities [PDF]

سیاست نامه علم و فناوری
Problem Statement: During the last two decades, many cities in the world have followed the idea of the ‘smart city’ to solve the issues of urban planning and governance using the capacity of modern information and communication technologies.
Behrouz Mohamadrezapour, Saeid Rafiepour , Meisam Alipour   +2 more
doaj