Results 131 to 140 of about 912,341 (301)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Particularismes de la recherche technologique au profit des personnes présentant une maladie d'Alzheimer ou un syndrome apparenté [PDF]

, 2013
National audienceTechnological research for those suffering Alzheimer disease or related syndromes is different both from regular technological and medical research. We are studying both the user its tool as one only topic.
Boudet, Blandine, Giacobini, Thérèse, Rumeau, Pierre, Vella, Frédéric, Vigouroux, Nadine   +4 more
core   +1 more source

Guidelines Towards Better Participation of Older Adults in Software Development Processes using a new SPIRAL Method and Participatory Approach

, 2018
This paper presents a new method of engaging older participants in the process of application and IT solutions development for older adults for emerging IT and tech startups.
Aula Anne, Knapp Jake, Naumanen Minnamari, Orzeszek D., Sanders Elizabeth B-N, Schumacher Jens   +5 more
core   +1 more source

The CHIARA Project: Addressing Women’s Mental Health and Safety in US–Mexico Border States

Medical Sciences Forum
The CHIARA Project investigates women’s mental health and vulnerability to sex trafficking in the U.S.–Mexico border states (California, Arizona, Texas, and New Mexico). A mixed-methods design was employed, combining qualitative content analysis of media,
Stephanie Meza, Gabriela Fernandez, Domenico Vito   +2 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Bottom-up radio: creating a new media format using living lab research [PDF]

, 2013
This study resulted in the creation of a new media format for urban youth, adopting a living lab-approach, as current studies have shown that this group is currently not reached with the contemporary media offer.
All, Anissa, Coorevits, Lynn, Schuurman, Dimitri   +2 more
core  

Safe system for sustainable development

Sustainable Earth Reviews
This paper presents a novel governance concept for sustainable development, introducing the 'Safe System Approach' as a transformative model that shifts focus from individual behavioural change to systemic transformation.
Oliver Lah
doaj   +1 more source

Living Lab-Based Service Interaction Design for a Companion Robot for Seniors in South Korea. [PDF]

Biomimetics (Basel), 2023
Kwon JY, Ju DY.
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Science Shops as key intermediary structures to respond to the current health research agenda bias: Evidence from the InSPIRES project

Health Expectations
Introduction To increase the likelihood of research responding to societal needs, intermediary structures such as Science Shops are being created.
Aina Estany, Fredrik Niclas Piro, Jacqueline E. W. Broerse, Rosina Malagrida   +3 more
doaj   +1 more source