Results 121 to 130 of about 912,341 (301)

Thought for Food: the impact of ICT on agribusiness [PDF]

, 2009
This report outlines the impact of ICT on the food economy. On the basis of a literature review from four disciplines - knowledge management, management information systems, operations research and logistics, and economics - the demand for new ICT ...
Bunte, F.H.J., Dijkxhoorn, Y., Groeneveld, R.E., Hofstede, G.J., Top, J.L., Vorst, J.G.A.J., van der, Wolfert, J.   +6 more
core   +2 more sources

Urban Forest Living Lab - ‘Urban Symbiosis’

Spool
This essay reports on a ‘living lab’ approach to develop a new understanding of below- and above-ground ecological processes as the foundation for robust urban forest habitats.
Jean-François Gauthier, Wiebke Klemm, Cecil C. Konijnendijk, Michiel Mol, Marco Roos, Nico Tillie, Rosa de Wolf, Roeland Lelieveld   +7 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

CLEF NewsREEL 2016: Comparing Multi-Dimensional Offline and Online Evaluation of News Recommender Systems [PDF]

, 2016
Running in its third year at CLEF, NewsREEL challenged participants to develop news recommendation algorithms and have them benchmarked in an online (Task 1) and offline setting (Task 2), respectively.
Brodt, Torben, Hopfgartner, Frank, Kille, Benjamin, Larson, Martha, Lommatzsch, Andreas, Malagoli, Davide, Seiler, Jonas, Sereny, Andras   +7 more
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Connecting with citizen journalists: an exploratory Living lab study on motivations for using mobile reporting applications [PDF]

, 2014
In the context of user generated content in the newsroom, mobile reporting applications are seen as a facilitator of citizen journalism, bringing news items from the user to the newsroom and vice versa.
Baccarne, Bastiaan, Schuurman, Dimitri, Vandenbroucke, Karel   +2 more
core  

A Review of Urban Living Labs Experiences with Emphasis on the Implementation of Environment-Based Smart Cities [PDF]

سیاست نامه علم و فناوری
Problem Statement: During the last two decades, many cities in the world have followed the idea of the ‘smart city’ to solve the issues of urban planning and governance using the capacity of modern information and communication technologies.
Behrouz Mohamadrezapour, Saeid Rafiepour , Meisam Alipour   +2 more
doaj  

Breaking the silos: integrated approaches to foster sustainable development and climate action

Sustainable Earth Reviews
A number of critical disconnects across sectors, actors continue to affect implementation action on sustainable development and climate action. Even when technical solutions, political commitments, and funding streams are avaiable, implementation often ...
Oliver Lah
doaj   +1 more source