Results 141 to 150 of about 2,732,997 (292)
Urban Forest Living Lab - ‘Urban Symbiosis’
SpoolThis essay reports on a ‘living lab’ approach to develop a new understanding of below- and above-ground ecological processes as the foundation for robust urban forest habitats.
Jean-François Gauthier +7 more
doaj +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Living Lab Toolbox - Toolbox to set and run a Living Lab
This toolbox is designed to support the PLAN’EAT Living Labs leaders in creating, developing, and maintaining their Living Labs (LL) in a sustainable matter. It defines a joint methodology for the use and purpose of a series of tools that cover the essential elements of setting up a Living Lab, including key aspects such as: · gathering a group ...
Kirschner, Jana +5 more
openaire +2 more sources
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
A Review of Urban Living Labs Experiences with Emphasis on the Implementation of Environment-Based Smart Cities [PDF]
سیاست نامه علم و فناوریProblem Statement: During the last two decades, many cities in the world have followed the idea of the ‘smart city’ to solve the issues of urban planning and governance using the capacity of modern information and communication technologies.
Behrouz Mohamadrezapour +2 more
doaj
Breaking the silos: integrated approaches to foster sustainable development and climate action
Sustainable Earth ReviewsA number of critical disconnects across sectors, actors continue to affect implementation action on sustainable development and climate action. Even when technical solutions, political commitments, and funding streams are avaiable, implementation often ...
Oliver Lah
doaj +1 more source
In het vak Living Lab Sustainable Places wordt ‘leren door tedoen’ omarmd. Bij aanvang van het vak presenteren verschillende opdrachtgevers hun sociaal-ruimtelijke vraagstuk aan de hele groepstudenten, waarna studententeams en opdrachtgevers aan elkaar gekoppeld worden.
van der Vaart, Gwenda, Grootjans, Niels
openaire +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source