Results 161 to 170 of about 2,732,997 (292)

The Senior Living Lab: an example of nursing leadership

, 2016
Susie Riva-Mossman, Thomas Kampel, Christine Cohen, Henk Verloo School of Nursing Sciences, La Source, University of Applied Sciences and Arts of Western Switzerland, Lausanne, Switzerland Abstract: The Senior Living Lab (SLL) is dedicated to the care ...
Verloo H, Riva-Mossman S, Kampel T, Cohen C   +3 more
core  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Thriving in the City: An Urban Living Lab to Facilitate Recovery From Psychosis. [PDF]

Early Interv Psychiatry
Abrahamyan Empson L, Conus P, Söderström O, Winz M, Vieira S, Favrod J, Ruggeri A, Brischoux J, Jordan A, Golay P.   +9 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Andorra as a living lab? The inSCI example. [PDF]

J Rehabil Med
Avellanet M, Stucki G, Pages E, Boada-Pladellorens A, Grillo C, Minoves-Triquell J, Bickenbach J.   +6 more
europepmc   +1 more source

"A living lab within a lab": approaches and challenges for scaling digital public health in resource-constrained settings. [PDF]

Front Public Health, 2023
Mukherjee AS, Sahay S, Kumar R, Banta R, Joshi N.   +4 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Tailoring the CFIR to Medication Adherence Interventions: A Delphi and Living Lab Study. [PDF]

Pharmacy (Basel)
Oude Lansink MAM, van den Bemt BJF, van de Steeg-van Gompel CHPA, Vervloet M, van Dijk L, Bekker CL.   +5 more
europepmc   +1 more source

DenCity Lab: Productive Working Living

, 2018
Amsterdam is an expanding city, Strategy planning for 2040 emphasises especially the potential for population number increase and significant economic growth.
Borowska, Agnieszka (author)
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source