Results 171 to 180 of about 2,732,997 (292)

The Living Lab Concept in the Detection, Prevention and Monitoring of Geriatric Syndromes in Elderly Patients with Cardiovascular Disease-A Narrative Review. [PDF]

J Clin Med
Pîslaru AI, Ștefăniu R, Baghiu MP, Istrate M, Albișteanu SM, Brumă BC, Turcu AM, Lungu ID, Ilie AC, Nistor I.   +9 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Toward a Brain Capital Living Lab model: multi-scale opportunities. [PDF]

Braz J Psychiatry, 2023
Eyre HA, Smith E, Ibanez A, Berk M.
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Use of a Living Lab Approach to Implement a Smoke-Free Campus Policy. [PDF]

Int J Environ Res Public Health, 2023
Mullin M, Allwright S, McGrath D, Hayes CB.   +3 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Identifying sport-for-development outcome measures suitable for a living-lab setting: a scoping review. [PDF]

BMC Sports Sci Med Rehabil
Sharma B, Xiao E, Bain J, Heal B, Antonio P, Timmons BW, Warner M.   +6 more
europepmc   +1 more source

Multicohort cross-sectional study of cognitive and behavioural digital biomarkers in neurodegeneration: the Living Lab Study protocol. [PDF]

BMJ Open, 2023
Crook-Rumsey M, Daniels SJC, Abulikemu S, Lai H, Rapeaux A, Hadjipanayi C, Soreq E, Li LM, Bashford J, Jeyasingh-Jacob J, Gruia DC, Lambert D, Weil R, Hampshire A, Sharp DJ, Haar S.   +15 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Identifying Facilitators and Obstacles in Piloting Dementia Initiatives Within a Living Lab Approach: Systematic Review. [PDF]

JMIR Aging
Alves S, Duarte N, Figueiredo T, Midao L, Bessa MJ, Rodriguéz O, Fidalgo J, Fernandez I, Felpete A, Rodriguéz M, Bernardéz JC, Facal D, Carrilho J, Costa E.   +13 more
europepmc   +1 more source