Results 181 to 190 of about 2,732,997 (292)

Social system design methodology for transitioning to a new social structure - a holistic urban living lab approach to the well-being city. [PDF]

Front Sociol, 2023
Kimura A, Haraguchi H, Yamauchi Y, Matsuura K.   +3 more
europepmc   +1 more source

Living Lab -toiminnan käynnistämisen haasteita ja menestystekijöitä

Opinnäytetyössä tutkittiin Living Lab -toiminnan käynnistämiseen liittyviä haasteita ja menestystekijöitä. Tutkimuksen tavoitteena oli selvittää, mitkä tekijät vaikuttavat projektin alkuvaiheen onnistumiseen ja kuinka ne voivat edistää toiminnan ...
Paananen, Katja
core  

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Field-Based Feasibility Assessment of Sorghum, Maize and Soybean for the Phytomanagement of Heavy Metal-Contaminated Mining Soils in a Living Lab Platform. [PDF]

Toxics
Ioniță MF, Dunca EC, Radu SM.
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

MSPEECH (multiple sclerosis monitoring through speech interaction in clinic and at home): a Living Lab study protocol for co-created, speech-based digital biomarkers in multiple sclerosis. [PDF]

Front Digit Health
Lemkau T, Inojosa H, Dillenseger A, Tröger J, Hermann J, Linz N, Gilbert S, Ziemssen T.   +7 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Identifying healthy and sustainable high-impact eating behaviour in French children aged 6-15 years: a combined multidisciplinary and living lab participatory approach. [PDF]

J Nutr Sci
Fardet A, Planchat-Héry C, Rock E, Bochan L.   +3 more
europepmc   +1 more source

Living Lab Experience in Turin: Lifestyles and Exposure to Black Carbon. [PDF]

Int J Environ Res Public Health, 2022
Salimbene O, Boniardi L, Lingua AM, Ravina M, Zanetti M, Panepinto D.   +5 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source