Results 131 to 140 of about 913,122 (305)
Breaking the silos: integrated approaches to foster sustainable development and climate action
Sustainable Earth ReviewsA number of critical disconnects across sectors, actors continue to affect implementation action on sustainable development and climate action. Even when technical solutions, political commitments, and funding streams are avaiable, implementation often ...
Oliver Lah
doaj +1 more source
The CHIARA Project: Addressing Women’s Mental Health and Safety in US–Mexico Border States
Medical Sciences ForumThe CHIARA Project investigates women’s mental health and vulnerability to sex trafficking in the U.S.–Mexico border states (California, Arizona, Texas, and New Mexico). A mixed-methods design was employed, combining qualitative content analysis of media,
Stephanie Meza +2 more
doaj +1 more source
Exploring Transient Territories for Biodesign: Design & Living Systems Lab [PDF]
, 2017 This paper examines the intersection of biology, biomimicry and design in the context of emergent sustainable practices that can impact of the fashion ...
Collet, Carole
core
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Health ExpectationsIntroduction To increase the likelihood of research responding to societal needs, intermediary structures such as Science Shops are being created.
Aina Estany +3 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Safe system for sustainable development
Sustainable Earth ReviewsThis paper presents a novel governance concept for sustainable development, introducing the 'Safe System Approach' as a transformative model that shifts focus from individual behavioural change to systemic transformation.
Oliver Lah
doaj +1 more source
Research protocol of the Laval-ROSA Transilab: a living lab on transitions for people living with dementia. [PDF]
BMC Health Serv Res, 2023 Dufour I +14 more
europepmc +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Mapping Public Sentiment: A Data-Driven Analysis of COVID-19 Discourse on Social Media in Italy
Medical Sciences ForumThis study provides a detailed analysis of COVID-19-related social media discourse in Italy, using 535,886 tweets from 10 major cities between 30 August 2020 and 8 June 2021. The tweets were translated from Italian to English for analysis. A multifaceted
Gabriela Fernandez +2 more
doaj +1 more source