Results 181 to 190 of about 913,122 (305)

Navigating Canada's primary care crisis: Living Lab approach to reduce administrative burden. [PDF]

Can Fam Physician
Gilfoyle M, Pearce S, Ha E, Kthupi A, Miceli L, Tibbles A, Agarwal P, Bhattacharyya O.   +7 more
europepmc   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Scaling success: parental perceptions of the benefits of a 20-week football living-lab approach for children living with cerebral palsy. [PDF]

BMJ Paediatr Open
Martins R, Pattison W, Vella L, Postlethwaite R, Broom D, Africa E, Duncan M.   +6 more
europepmc   +1 more source

Living labs for patient engagement and knowledge exchange: an exploratory sequential mixed methods study to develop a living lab in paediatric rehabilitation. [PDF]

BMJ Open, 2021
Archibald MM, Wittmeier K, Gale M, Ricci F, Russell K, Woodgate RL.   +5 more
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Creating and sustaining enabling systems and communities to address social needs: protocol for a living lab social prescribing study. [PDF]

BMC Prim Care
Oster C, Powell A, Hutchinson C, Faghidno S, Bogomolova S.   +4 more
europepmc   +1 more source

Rationale and Methods of Evaluation for ACHO, A New Virtual Assistant to Improve Therapeutic Adherence in Rural Elderly Populations: A User-Driven Living Lab. [PDF]

Int J Environ Res Public Health, 2021
Luengo-Polo J, Conde-Caballero D, Rivero-Jiménez B, Ballesteros-Yáñez I, Castillo-Sarmiento CA, Mariano-Juárez L.   +5 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Preliminary User-Centred Evaluation of a Bio-Cooperative Robotic Platform for Cognitive Rehabilitation in Parkinson's Disease and Mild Cognitive Impairment: Insights from a Focus Group and Living Lab in the OPERA Project. [PDF]

J Clin Med
Crocetto Y, Abagnale S, Martinelli G, Della Bella S, Pavan E, Rondoni C, Voscarelli A, Pirini M, Scotto di Luzio F, Zollo L, Cicarelli G, Polito C, Estraneo A.   +12 more
europepmc   +1 more source