Results 81 to 90 of about 237,580 (299)
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Comparison of Health and Wellbeing Living Lab Business Models : Preliminary result based on Business Model Canvas Evaluation [PDF]
, 2018 The most popular thematic focus area among ENoLL members is the health and wellbeing, which covers nearly a half of all the certified Living Labs. However, the studies evaluating Living Lab (LL) business models in general and especially those focusing on
Julin, Mikko, Santonen, Teemu
core +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Positioning urban labs – a new form of smart governance? [PDF]
, 2016 In the current era, in which cities are considered key arenas for coping with a number of societal challenges, there is also renewed interest in the mobilisation of experimental practices within urban planning. A growing interest in innovative intiatives
Perjo, Liisa +3 more
core
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Interdisciplinary Journal of Partnership StudiesCampus-community partnerships are well-positioned to play a role in advancing social and environmental justice in the context of our rapidly changing and increasingly inequitable world. Across the Global North, post-secondary institutions, civil society
Charles Z. Levkoe +6 more
doaj +1 more source
The role of urban living labs in a smart city [PDF]
, 2014 In a rapidly changing socio-technical environment cities are increasingly seen as main drivers for change. Against this backdrop, this paper studies the emerging Urban Living Lab and Smart City concepts from a project based perspective, by assessing a ...
Baccarne, Bastiaan +3 more
core
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Living Labs as a Form of Innovation Development
Management and Business Administration. Central Europe, 2013 Purpose: The general purpose of this paper is to present living labs as a new form of innovation activity based on the concept of user-driven innovation. More specifi c goals are to show the development of living labs around the world and to identify the
Wanda Pełka
doaj